Insulin signaling impairment in the brain as a risk factor in Alzheimer's disease

C Hölscher - Frontiers in aging neuroscience, 2019 - frontiersin.org
Type 2 diabetes is a risk factor for developing Alzheimer's disease (AD). The underlying
mechanism that links up the two conditions seems to be the de-sensitization of insulin …

Metabolic disorder in Alzheimer's disease

MK Poddar, S Banerjee, A Chakraborty, D Dutta - Metabolic brain disease, 2021 - Springer
Abstract Alzheimer's disease (AD), a well known aging-induced neurodegenerative disease
is related to amyloid proteinopathy. This proteinopathy occurs due to abnormalities in …

Vascular dementia subtypes, pathophysiology, genetics, neuroimaging, biomarkers, and treatment updates along with its association with Alzheimer's dementia and …

P Prajjwal, MDM Marsool, P Inban, B Sharma… - Disease-a-Month, 2023 - Elsevier
Dementia is a chronic progressive cognitive decline illness that results in functional
impairment. Vascular dementia (VaD), second only to Alzheimer's disease (AD), is one of …

Blood pressure and Alzheimer's disease: A review of meta-analysis

O Saiz-Vazquez, A Puente-Martinez… - Frontiers in …, 2023 - frontiersin.org
Background Alzheimer's disease (AD) is a neurological disorder of unknown cause,
resulting in the death of brain cells. Identifying some of the modifiable risk factors for AD …

Renin-angiotensin system and Alzheimer's disease pathophysiology: from the potential interactions to therapeutic perspectives

VT Ribeiro, LC de Souza… - Protein and Peptide …, 2020 - ingentaconnect.com
New roles of the Renin-Angiotensin System (RAS), apart from fluid homeostasis and Blood
Pressure (BP) regulation, are being progressively unveiled, since the discoveries of RAS …

Hypertension linked to Alzheimer's disease via stroke: Mendelian randomization

C Tang, Y Ma, X Lei, Y Ding, S Yang, D He - Scientific Reports, 2023 - nature.com
This study aimed to investigate the relationship between hypertension and Alzheimer's
disease (AD) and demonstrate the key role of stroke in this relationship using mediating …

Lifestyle intervention to prevent Alzheimer's disease

Y Ko, SM Chye - Reviews in the Neurosciences, 2020 - degruyter.com
Alzheimer's disease (AD) is the most common neurodegenerative disease that leads to
significant morbidities in elderly. The major pathological hallmark of AD is beta-amyloid …

A novel model of mixed vascular dementia incorporating hypertension in a rat model of Alzheimer's disease

P Denver, H D'Adamo, S Hu, X Zuo, C Zhu… - Frontiers in …, 2019 - frontiersin.org
Alzheimer's disease (AD) and mixed dementia (MxD) comprise the majority of dementia
cases in the growing global aging population. MxD describes the coexistence of AD …

A review of the mechanisms underlying selected comorbidities in Alzheimer's disease

K Maciejewska, K Czarnecka, P Szymański - Pharmacological Reports, 2021 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) leading to mental deterioration and devastation, and eventually a …

Hypertension, diabetes and neurodegenerative diseases: is there a clinical link through the Ca2+/cAMP signalling interaction?

LB Bergantin - Current hypertension reviews, 2019 - ingentaconnect.com
Background: Hypertension, diabetes and neurodegenerative diseases are among the most
prevalent medical problems around the world, costing millions of dollars to the medical …