Hallmarks of brain aging: adaptive and pathological modification by metabolic states

MP Mattson, TV Arumugam - Cell metabolism, 2018 - cell.com
During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

Obesity-induced neuroinflammation: beyond the hypothalamus

O Guillemot-Legris, GG Muccioli - Trends in neurosciences, 2017 - cell.com
Obesity is now a worldwide health issue. Far from being limited to weight gain, obesity is
generally associated with low-grade inflammation and with a cluster of disorders collectively …

Neurological consequences of obesity

PD O'Brien, LM Hinder, BC Callaghan… - The Lancet …, 2017 - thelancet.com
The high prevalence of obesity is associated with an enormous medical, social, and
economic burden. The metabolic dysfunction, dyslipidaemia, and inflammation caused by …

The anti-inflammatory activity of licorice, a widely used Chinese herb

R Yang, BC Yuan, YS Ma, S Zhou, Y Liu - Pharmaceutical biology, 2017 - Taylor & Francis
Context: Increasing incidence and impact of inflammatory diseases have encouraged the
search of new pharmacological strategies to face them. Licorice has been used to treat …

Therapies for prevention and treatment of Alzheimer's disease

J Mendiola-Precoma, LC Berumen… - BioMed research …, 2016 - Wiley Online Library
Alzheimer's disease (AD) is the most common cause of dementia associated with a
progressive neurodegenerative disorder, with a prevalence of 44 million people throughout …

Neurotrophic and neuroregenerative effects of GH/IGF1

VE Bianchi, V Locatelli, L Rizzi - International journal of molecular …, 2017 - mdpi.com
Introduction. Human neurodegenerative diseases increase progressively with age and
present a high social and economic burden. Growth hormone (GH) and insulin-like growth …

Dietary habits, lifestyle factors and neurodegenerative diseases

A Popa-Wagner, DI Dumitrascu… - Neural regeneration …, 2020 - journals.lww.com
Worldwide stroke is increasing in parallel with modernization, changes in lifestyle, and the
growing elderly population. Our review is focused on the link between diet, as part of …

Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid

N Yanguas‐Casás, A Crespo‐Castrillo… - Glia, 2018 - Wiley Online Library
Sex differences in the incidence, clinical manifestation, disease course, and prognosis of
neurological diseases, such as autism spectrum disorders or Alzheimer's disease, have …

Equol, a dietary daidzein gut metabolite attenuates microglial activation and potentiates neuroprotection in vitro

L Subedi, E Ji, D Shin, J Jin, JH Yeo, SY Kim - Nutrients, 2017 - mdpi.com
Estrogen deficiency has been well characterized in inflammatory disorders including
neuroinflammation. Daidzein, a dietary alternative phytoestrogen found in soy (Glycine max) …

Menopause, obesity and inflammation: interactive risk factors for Alzheimer's disease

A Christensen, CJ Pike - Frontiers in aging neuroscience, 2015 - frontiersin.org
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, the development of
which is regulated by several environmental and genetic risk factors. Two factors theorized …