Rolling circle amplification (RCA) is an isothermal enzymatic process where a short DNA or
RNA primer is amplified to form a long single stranded DNA or RNA using a circular DNA …

Enhancing the limit of detection (LOD) is significant for crucial diseases. Cancer
development could take more than 10 years, from one mutant cell to a visible tumor. Early …

Using DNA as programmable, sequence-specific 'glues', shape-controlled hydrogel units
are self-assembled into prescribed structures. Here we report that aggregates are produced …

There is great demand for flexible biomolecule analysis platforms that can precisely quantify
very low levels of multiple targets directly in complex biological samples. Herein we …

Single-molecule fluorescence imaging is among the most advanced analytical technologies
and has been widely adopted for biosensing due to its distinct advantages of simplicity …

Extracellular vesicle‐derived microRNA (EV‐miRNA) represent a promising cancer
biomarker for disease diagnosis and monitoring. However, existing techniques to detect EV …

An exonucleolytic digestion-assisted exponential rolling circle amplification (RCA) strategy
was developed for sensitive and sequence-specific detection of target DNA embedded in …

Rolling circle amplification (RCA) is a simple and isothermal DNA amplification technique
that is used to generate thousands of repeating DNA sequences using circular templates …

The use of nucleic acids as components in highly sensitive biosensors has attracted
increasing interest during recent years, not least due to the ease by which nucleic acids can …

An on-nanoparticle rolling-circle amplification (nanoRCA) strategy allows the visual
detection of 30 molecules of carcinoembryonic antigen with at least 10 10-fold selectivity …