The main objective of antigen processing is to orchestrate the selection of immunodominant
epitopes for recognition by CD4 T cells. To achieve this, MHC class II molecules have …

Select humans and animals control persistent viral infections via adaptive immune
responses that include production of neutralizing antibodies. The precise genetic basis for …

Cytotoxic T lymphocytes constantly monitor peptide-MHC class I complexes on the cell
surface to eliminate transformed and virally infected cells expressing peptides derived from …

DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclassical major
histocompatibility complex class II (MHC II) accessory molecule mainly expressed in the …

Introduction HLA-DO (DO) is an accessory protein that binds DM for trafficking to MIIC and
has peptide editing functions. DO is mainly expressed in thymic medulla and B cells. Using …

Background The outcomes of ovarian cancer patients are very poor, therefore it is necessary
to find prognostic biomarkers and explore the potential underlying molecular mechanisms of …

HCV infection represents a worldwide health problem with many attempts to control. This
study aimed to assess the relation between HLA-DQ-rs3920 SNP, HLA-DP-rs3077 SNP …

Recent many studies indicated a novel dinucleotide variant in ss469415590 (TT vs. ΔG) of
interferon-λ 4 (IFNL4) gene strongly associated with hepatitis C virus clearance. To evaluate …

A recent genome-wide association study (GWAS) has identified the single-nucleotide
polymorphism (SNP) rs4273729 in a 100-kbp region comprising human leukocyte antigens …

Genetic variation of related genes in Vitamin D (VD) metabolic pathway played an important
role in antiviral immune response and chronic hepatitis C virus (HCV) infection. Retinoid X …