Mutations of the retinoblastoma tumour suppressor gene (RB1) or components regulating
the RB pathway have been identified in almost every human malignancy. The E2F …

People are continuously exposed exogenously to varying amounts of chemicals that have
been shown to have carcinogenic or mutagenic properties in experimental systems …

Genetic and biochemical studies in lower eukaryotes have identified several proteins that
ensure accurate segregation of chromosomes. These include the Drosophila aurora and …

This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer
pathophysiology by identifying associations between recurrent CNAs, gene expression, and …

Autophagy is a bulk degradation process that promotes survival under metabolic stress, but
it can also be a means of cell death if executed to completion. Monoallelic loss of the …

The centrosomes are thought to maintain genomic stability through the establishment of
bipolar spindles during cell division, ensuring equal segregation of replicated chromosomes …

The simultaneous and unequivocal discernment of all human chromosomes in different
colors would be of significant clinical and biologic importance. Whole-genome scanning by …

Autophagy is a catabolic process involving self-digestion of cellular organelles during
starvation as a means of cell survival; however, if it proceeds to completion, autophagy can …

Members of the recently recognized SRC-1 family of transcriptional coactivators interact with
steroid hormone receptors to enhance ligand-dependent transcription. AIB1, a member of …

Last year marked the 40th anniversary of the publication of the first print edition of Mendelian
Inheritance in Man (MIM). 1 This seems an appropriate juncture at which to review its …