Tissue hypoxia results from an inadequate supply of oxygen (O2) that compromises biologic
functions. Evidence from experimental and clinical studies increasingly points to a …

Lung cancer remains a major threat to human health. Low dose CT scan (LDCT) has
become the main method of early screening for lung cancer due to the low sensitivity of …

Abstract Individuals with Li-Fraumeni syndrome carry inherited mutations in the p53 tumor
suppressor gene and are predisposed to tumor development. To examine the mechanistic …

The utilization of gold nanoparticles (AuNPs) as radiosensitizers has shown great promise in
pre-clinical research. In the current review, the physical, chemical, and biological pathways …

Notch‐ligand interactions are a highly conserved mechanism that regulates cell fate
decisions. Over the past few years, numerous observations have shown that this mechanism …

The Kelch-like ECH-associated protein 1 (Keap1)–nuclear factor E2-related factor 2 (Nrf2)
pathway is one of the major signaling cascades involved in cell defense and survival against …

Inhibitory regulators of apoptosis play a critical role in the responsiveness of tumour cells to
cytotoxic agents. The X-linked inhibitor of apoptosis protein (XIAP) is a member of a novel …

Using an in vitro translation assay to screen a human brain cDNA library, we isolated the
microtubule-associated protein Tau and determined it to be a caspase-3 substrate whose C …

The whole-cell inorganic-biohybrid systems show special functions and wide potential in
biomedical application owing to the exceptional interactions between microbes and …

Purpose Much of the volume of solid tumors typically exists in a chronically hypoxic
microenvironment that has been shown to result in both chemotherapy and radiation therapy …