The AAA+ superfamily of ATPases, which contain a homologous ATPase module, are found
in all kingdoms of living organisms where they participate in diverse cellular processes …

In all eukaryotes, a microtubule-based structure known as the spindle is responsible for
accurate chromosome segregation during cell division. Spindle assembly and function …

Complete genomic sequence is known for two multicellular eukaryotes, the nematode
Caenorhabditis elegans and the fruit fly Drosophila melanogaster, and it will soon be known …

Programmed destruction of regulatory proteins through the ubiquitin–proteasome system is
a widely used mechanism for controlling signalling pathways,. Cullins are proteins that …

The concentrations and functions of many cellular proteins are regulated by the ubiquitin
pathway. Cullin family proteins bind with the RING-finger protein Roc1 to recruit the ubiquitin …

Cullin‐based E3 ligases target substrates for ubiquitin‐dependent degradation by the 26S
proteasome. The SCF (Skp1–Cul1–F‐box) and ECS (ElonginC–Cul2–SOCS box) …

ASPM (known as Asp in fly and ASPM-1 in worm) is a microcephaly-associated protein
family that regulates spindle architecture, but the underlying mechanism is poorly …

Many biological processes, such as development and cell cycle progression are tightly
controlled by selective ubiquitin-dependent degradation of key substrates. In this pathway …

Spastin, the most common locus for mutations in hereditary spastic paraplegias, and katanin
are related microtubule-severing AAA ATPases,,,, involved in constructing neuronal,,, and …

ATP-dependent severing of microtubules was first reported in Xenopus laevis egg extracts in
1991. Two years later this observation led to the purification of the first known microtubule …