[HTML][HTML] A unique family of neuronal signaling proteins implicated in oncogenesis and tumor suppression
M Hartl, R Schneider - Frontiers in Oncology, 2019 - frontiersin.org
The neuronal proteins GAP43 (neuromodulin), MARCKS, and BASP1 are highly expressed
in the growth cones of nerve cells where they are involved in signal transmission and …
in the growth cones of nerve cells where they are involved in signal transmission and …
Downregulation of BASP1 promotes temozolomide resistance in gliomas via epigenetic activation of the FBXO32/NF-κB/MGMT axis
X Liao, Z Li, H Zheng, W Qian, S Zhang, S Chen… - Molecular Cancer …, 2023 - AACR
The chemoresistance of temozolomide-based therapy is a serious limitation for lasting
effective treatment of gliomas, while the underlying mechanisms remain unclear. In this …
effective treatment of gliomas, while the underlying mechanisms remain unclear. In this …
Quantitative proteomics identifies brain acid soluble protein 1 (BASP1) as a prognostic biomarker candidate in pancreatic cancer tissue
Q Zhou, R Andersson, D Hu, M Bauden, T Kristl… - …, 2019 - thelancet.com
Background Pancreatic cancer is a heterogenous disease with a poor prognosis. This study
aimed to discover and validate prognostic tissue biomarkers in pancreatic cancer using a …
aimed to discover and validate prognostic tissue biomarkers in pancreatic cancer using a …
[HTML][HTML] Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression
CC Lin, YK Huang, CF Cho, YS Lin, CC Lo, TT Kuo… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Brain metastasis in patients with lung cancer is life-threatening. However, the
molecular mechanism for this catastrophic disease remains elusive, and few druggable …
molecular mechanism for this catastrophic disease remains elusive, and few druggable …
Cholesterol is required for transcriptional repression by BASP1
AE Loats, S Carrera, AF Fleming… - Proceedings of the …, 2021 - National Acad Sciences
Lipids are present within the cell nucleus, where they engage with factors involved in gene
regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome …
regulation. Cholesterol associates with chromatin in vivo and stimulates nucleosome …
[HTML][HTML] Targeting pin1 by all-trans retinoic acid (ATRA) overcomes tamoxifen resistance in breast cancer via multifactorial mechanisms
S Huang, Y Chen, ZM Liang, NN Li, Y Liu… - Frontiers in cell and …, 2019 - frontiersin.org
Breast cancer is the most prevalent tumor in women worldwide and about 70% patients are
estrogen receptor positive. In these cancer patients, resistance to the anticancer estrogen …
estrogen receptor positive. In these cancer patients, resistance to the anticancer estrogen …
The brain acid‐soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin
M Hartl, K Puglisi, A Nist, P Raffeiner… - Molecular …, 2020 - Wiley Online Library
The MYC protein is a transcription factor with oncogenic potential controlling fundamental
cellular processes such as cell proliferation, metabolism, differentiation, and apoptosis. The …
cellular processes such as cell proliferation, metabolism, differentiation, and apoptosis. The …
Immunoproteasome function maintains oncogenic gene expression in KMT2A-complex driven leukemia
N Tubío-Santamaría, AK Jayavelu, TM Schnoeder… - Molecular Cancer, 2023 - Springer
Pharmacologic targeting of chromatin-associated protein complexes has shown significant
responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance …
responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance …
Mechanistic study of lncRNA UCA1 promoting growth and cisplatin resistance in lung adenocarcinoma
J Fu, J Pan, X Yang, Y Zhang, F Shao, J Chen… - Cancer Cell …, 2021 - Springer
Aim This study aimed to explore the mechanism of LncRNA urothelial carcinoma-associated
1 (UCA1) promoting cisplatin resistance in lung adenocarcinoma (LUAD). Method The …
1 (UCA1) promoting cisplatin resistance in lung adenocarcinoma (LUAD). Method The …
A high-affinity cocaine binding site associated with the brain acid soluble protein 1
Cocaine exerts its stimulant effect by inhibiting dopamine (DA) reuptake, leading to
increased dopamine signaling. This action is thought to reflect the binding of cocaine to the …
increased dopamine signaling. This action is thought to reflect the binding of cocaine to the …