Frontotemporal dementia (FTD), the second most common type of presenile dementia, is a
heterogeneous neurodegenerative disease characterized by progressive behavioural …

Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of disorders
characterized by disturbances of behavior and personality and different types of language …

We and others have reported heterozygous progranulin mutations as an important cause of
frontotemporal lobar degeneration (FTLD). It has been identified a complete progranulin …

Frontotemporal dementia (FTD) is the most frequently occurring dementia in the presenile
population. Despite epidemiologic data showing that patients with FTD may have …

The intercellular transfer of amyloid-β (Aβ) and tau proteins has received increasing
attention in Alzheimer's disease (AD). Among other transfer modes, Aβ and tau …

Background A hexanucleotide repeat expansion in the first intron of C9ORF72 has been
shown to be responsible for a high number of familial cases of amyotrophic lateral sclerosis …

Background We explored the diagnostic performance of cerebrospinal fluid (CSF)
biomarkers in allowing differentiation between frontotemporal lobar degeneration (FTLD) …

Importance Histone deacetylase inhibitors have been repeatedly shown to elevate
progranulin levels in preclinical models. This report describes the first randomized clinical …

There is an unmet need for markers that can stratify different forms and subtypes of
dementia. Because of similarities in clinical presentation, it can be difficult to distinguish …

A hexanucleotide repeat expansion in the first intron of C9ORF72 has been shown to be
responsible for a high number of familial cases of amyotrophic lateral sclerosis or …