DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk
factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma …

MicroRNAs (miRNAs) are endogenous small non-coding RNAs with the capacity to regulate
gene expression post-transcriptionally. The miRNA-29 family consists of miR-29a, miR-29b …

It has been two decades since investigators discovered the link between the Drosophila
wingless (Wg) gene and the vertebrate oncogene int-1, thus establishing the family of …

Nasopharyngeal carcinoma (NPC) is a head and neck cancer rare throughout most of the
world but common in certain geographic areas, such as southern Asia. While environmental …

Treating the osteosarcoma (OSA) remains a challenge. Current strategies focus on the
primary tumor and have limited efficacy for metastatic OSA. A better understanding of the …

Nasopharyngeal carcinoma (NPC) is a rare malignancy in most part of the world and it is
one of the most confusing, commonly misdiagnosed and poorly understood diseases. The …

Abstract BACKGROUND: Epstein‐Barr virus (EBV) microRNAs are abundant in
nasopharyngeal carcinoma (NPC) tumors. With recent advances in serum microRNA …

It has been reported that the progression of osteosarcoma was closely associated with the
aberrant activation of canonical Wnt signaling. Wnt inhibitory factor-1 (WIF-1) is a secreted …

Abstract Background Aberrations in the Wnt pathway have been reported to be involved in
the metastasis of prostate cancer (PCa) to bone. We investigated the effect and underlying …