Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

The circadian clock evolved in diverse organisms to integrate external environmental
changes and internal physiology. The clock endows the host with temporal precision and …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Immune responses are gated to protect the host against specific antigens and microbes, a
task that is achieved through antigen-and pattern-specific receptors. Less appreciated is that …

Introduction The circadian circuit, a roughly 24 h molecular feedback loop, or clock, is
conserved from bacteria to animals and allows for enhanced organismal survival by …

Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …

Amplified innate leukocytes (neutrophils and monocytes/macrophages) are associated with
advanced ischemic and non-ischemic heart failure (HF). Intensified neutrophilic leukocytosis …

The impact of circadian rhythms on cardiovascular function and disease development is well
established, with numerous studies in genetically modified animals emphasizing the …

Circadian rhythms exert a profound impact on most aspects of mammalian physiology,
including the immune and cardiovascular systems. Leukocytes engage in time-of-day …

Myocardial ischemia-reperfusion injury (MIRI), the joint result of ischemic injury and
reperfusion injury, is associated with poor outcomes in patients with acute myocardial …