It is widely suggested that a eukaryotic mRNA typically contains one translation start site and
encodes a single functional protein product. However, according to current points of view on …

The molecular mechanisms underlying the homeostatic modulation of presynaptic
neurotransmitter release are largely unknown. We have previously used an …

Type 2 diabetes is partly characterized by decreased β-cell mass and function which have
been linked to cellular senescence. Despite a low basal proliferative rate of adult β-cells …

Our previous studies on melanoma antigens identified two new polypeptides, named
MELOE-1 and MELOE-2, that are involved in immunosurveillance. Intriguingly, these …

In the context of the FlyBase annotated gene models in Drosophila melanogaster, we
describe the many exceptional cases we have curated from the literature or identified in the …

HemK2 is a highly conserved methyltransferase, but the identification of its genuine
substrates has been controversial, and its biological importance in higher organisms …

Eukaryotic mRNAs are generally considered monocistronic and encode only one protein.
Although dicistronic mRNAs encoding two proteins were found in fungi, plants, and animals …

We identified a Drosophila homologue that belongs to a subfamily of the mammalian
peroxiredoxin 5 genes. The Drosophila peroxiredoxin 5 (dPrx 5) gene corresponds to …

A continuous supply of fusion-competent synaptic vesicles is essential for sustainable
neurotransmission. Drosophila mutations of the dicistronic stoned locus disrupt normal …

Advances in sequencing technology have unveiled examples of nucleus-encoded
polycistronic genes, once considered rare. Exclusively polycistronic transcripts are prevalent …