The steady progress in genome editing, especially genome editing based on the use of
clustered regularly interspaced short palindromic repeats (CRISPR) and programmable …

Simple Summary Clustered regularly interspaced short palindromic repeats (CRISPR)-
CRISPR associated protein (Cas) 9 is a novel technology utilized to modify target genes …

Programmed cell death ligand 1 (PD-L1) is a transmembrane protein that is expressed on
tumor cells that suppresses the T cell-mediated immune response. Therapies targeting the …

Genome engineering is a powerful tool for a wide range of applications in biomedical
research and medicine. The development of the clustered regularly interspaced short …

This is a spectacular moment for genetics to evolve in genome editing, which encompasses
the precise alteration of the cellular DNA sequences within various species. One of the most …

Abstract Advances in Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR
associated system (CRISPR/Cas9) has dramatically reshaped our ability to edit genomes …

Objective (s): Multidrug resistance (MDR) is a major obstacle in the successful
chemotherapy of ovarian cancer. Inhibition of P-glycoprotein (P-gp), a member of ATP …

All human genes undergo alternative splicing leading to the diversity of the proteins.
However, in some cases, abnormal regulation of alternative splicing can result in diseases …

Metastatic cells exhibit an extraordinary phenotypic plasticity, not only in adapting to
unfamiliar microenvironments but also in surviving aggressive treatments and immune …

Ovarian cancer is among the most lethal gynecological cancers, primarily due to the lack of
specific symptoms leading to an advanced-stage diagnosis and resistance to chemotherapy …