Tissue injury triggers a complex series of cellular responses, starting from inflammation
activated by tissue and cell damage and proceeding to healing. By clearing cell debris …

Atrophy is a classical hallmark of an array of disorders that affect skeletal muscle, ranging
from inherited dystrophies, acquired inflammatory myopathies, ageing (sarcopenia) and …

Depending on the inflammatory milieu, injury can result either in a tissue's complete
regeneration or in its degeneration and fibrosis, the latter of which could potentially lead to …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Immunological and inflammatory processes downstream of dystrophin deficiency as well as
metabolic abnormalities, defective autophagy, and loss of regenerative capacity all …

Current molecular genomic approaches to human genetic disorders have led to an
explosion in the identification of the genes and their encoded proteins responsible for these …

Skeletal muscle regeneration is highly dependent on the inflammatory response. A wide
variety of innate and adaptive immune cells orchestrate the complex process of muscle …

Adult skeletal muscle has a robust capacity for self-repair, owing to synergies between
muscle satellite cells and the immune system. In vitro models of muscle self-repair would …

Duchenne muscular dystrophy (DMD) is caused by mutations in the gene that encodes the
427‐kDa cytoskeletal protein dystrophin. Increased knowledge of the function of dystrophin …

To withstand the rigors of contraction, muscle fibers have specialized protein complexes that
buffer against mechanical stress and a multifaceted repair system that is rapidly activated …