Integrin adhesion complexes (IACs) have evolved over millions of years to integrate
metazoan cells physically with their microenvironment. It is presumed that the simultaneous …

Acting as a bridge between the cytoskeleton of the cell and the extra cellular matrix (ECM),
the cell-ECM adhesions with integrins at their core, play a major role in cell signalling to …

Integrin receptor activation initiates the formation of integrin adhesion complexes (IACs) at
the cell membrane that transduce adhesion-dependent signals to control a multitude of …

Collagens are the most abundant proteins in mammals. The collagen family comprises 28
members that contain at least one triple-helical domain. Collagens are deposited in the …

Extracellular vesicles are emerging as a potent mechanism of intercellular communication
because they can systemically exchange genetic and protein material between cells …

Cell adhesions mediate important bidirectional interactions between cells and the
extracellular matrix. They provide an interactive interface between the extracellular chemical …

The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal
and extracellular matrix networks. The connection between integrins and the cytoskeleton is …

Integrin-containing focal adhesions transmit extracellular signals across the plasma
membrane to modulate cell adhesion, signalling and survival. Although integrins are known …

Cell division, the purpose of which is to enable cell replication, and in particular to distribute
complete, accurate copies of genetic material to daughter cells, is essential for the …

The ability of animal cells to sense, adhere to and remodel their local extracellular matrix
(ECM) is central to control of cell shape, mechanical responsiveness, motility and signalling …