Protein misfolding, amyloid formation, and human disease: a summary of progress over the last decade
Peptides and proteins have been found to possess an inherent tendency to convert from
their native functional states into intractable amyloid aggregates. This phenomenon is …
their native functional states into intractable amyloid aggregates. This phenomenon is …
Cellular functions of the amyloid precursor protein from development to dementia
R Van Der Kant, LSB Goldstein - Developmental cell, 2015 - cell.com
Amyloid precursor protein (APP) is a key player in Alzheimer's disease (AD). The Aβ
fragments of APP are the major constituent of AD-associated amyloid plaques, and …
fragments of APP are the major constituent of AD-associated amyloid plaques, and …
The mechanism of γ‐secretase dysfunction in familial Alzheimer disease
L Chávez‐Gutiérrez, L Bammens, I Benilova… - The EMBO …, 2012 - embopress.org
The mechanisms by which mutations in the presenilins (PSEN) or the amyloid precursor
protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD …
protein (APP) genes cause familial Alzheimer disease (FAD) are controversial. FAD …
Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's …
KR Sadleir, PC Kandalepas, V Buggia-Prévot… - Acta …, 2016 - Springer
Alzheimer's disease (AD) is characterized by amyloid plaques composed of the β-amyloid
(Aβ) peptide surrounded by swollen presynaptic dystrophic neurites consisting of …
(Aβ) peptide surrounded by swollen presynaptic dystrophic neurites consisting of …
Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation
A Ochalek, B Mihalik, HX Avci… - Alzheimer's research & …, 2017 - Springer
Background Alzheimer's disease (AD) is the most common type of dementia, affecting one in
eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown …
eight adults over 65 years of age. The majority of AD cases are sporadic, with unknown …
Untangling genetic risk for Alzheimer's disease
Alzheimer's disease (AD) is a genetically heterogeneous neurodegenerative disorder
caused by fully penetrant single gene mutations in a minority of cases, while the majority of …
caused by fully penetrant single gene mutations in a minority of cases, while the majority of …
Molecular mechanisms of Alzheimer disease protection by the A673T allele of amyloid precursor protein
JA Maloney, T Bainbridge, A Gustafson, S Zhang… - Journal of Biological …, 2014 - ASBMB
Pathogenic mutations in the amyloid precursor protein (APP) gene have been described as
causing early onset familial Alzheimer disease (AD). We recently identified a rare APP …
causing early onset familial Alzheimer disease (AD). We recently identified a rare APP …
Alzheimer's disease: How metal ions define β-amyloid function
KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …
The genes associated with early-onset Alzheimer's disease
MH Dai, H Zheng, LD Zeng, Y Zhang - Oncotarget, 2017 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that accounts for the
most cases of dementia, which is characterized by the deposition of dense plaques of …
most cases of dementia, which is characterized by the deposition of dense plaques of …
Genomics of Alzheimer disease: a review
RN Rosenberg, D Lambracht-Washington, G Yu… - JAMA …, 2016 - jamanetwork.com
Importance To provide a comprehensive review of knowledge of the genomics of Alzheimer
disease (AD) and DNA amyloid β 42 (Aβ42) vaccination as a potential therapy. Observations …
disease (AD) and DNA amyloid β 42 (Aβ42) vaccination as a potential therapy. Observations …