Pharmacological properties of trichostatin A, focusing on the anticancer potential: a comprehensive review
A Bouyahya, N El Omari, M Bakha, T Aanniz… - Pharmaceuticals, 2022 - mdpi.com
Trichostatin A (TSA), a natural derivative of dienohydroxamic acid derived from a fungal
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …
metabolite, exhibits various biological activities. It exerts antidiabetic activity and reverses …
PR-619, a general inhibitor of deubiquitylating enzymes, diminishes cisplatin resistance in urothelial carcinoma cells through the suppression of c-Myc: an in vitro and …
Cisplatin-based chemotherapy is the standard treatment for bladder urothelial carcinoma
(UC). Most patients experience chemoresistance, the primary cause of treatment failure …
(UC). Most patients experience chemoresistance, the primary cause of treatment failure …
Trifluoperazine, an antipsychotic drug, effectively reduces drug resistance in cisplatin-resistant urothelial carcinoma cells via suppressing Bcl-xL: an in vitro and in vivo …
Cisplatin-based chemotherapy is the primary treatment for metastatic bladder urothelial
carcinoma (UC). Most patients inevitably encounter drug resistance and resultant disease …
carcinoma (UC). Most patients inevitably encounter drug resistance and resultant disease …
Phosphorylation of Neurofilament Light Chain in the VLO Is Correlated with Morphine-Induced Behavioral Sensitization in Rats
YX Zhang, YM Zhu, XX Yang, FF Gao, J Chen… - International Journal of …, 2023 - mdpi.com
Neurofilament light chain (NF-L) plays critical roles in synapses that are relevant to
neuropsychiatric diseases. Despite postmortem evidence that NF-L is decreased in opiate …
neuropsychiatric diseases. Despite postmortem evidence that NF-L is decreased in opiate …
Histone deacetylase inhibitor, trichostatin A, synergistically enhances paclitaxel-induced cytotoxicity in urothelial carcinoma cells by suppressing the ERK pathway
FS Hsu, JT Wu, JY Lin, SP Yang, KL Kuo… - International Journal of …, 2019 - mdpi.com
Trichostatin A (TSA), an antifungal antibiotic derived from Streptomyces, inhibits mammalian
histone deacetylases, and especially, selectively inhibits class I and II histone deacetylase …
histone deacetylases, and especially, selectively inhibits class I and II histone deacetylase …
MiR-320a is associated with cisplatin resistance in lung adenocarcinoma and its clinical value in non-small cell lung cancer: A comprehensive analysis based on …
M Lu, C Hu, F Wu, L Shu, Y Pan, X Liu, P Liu, F Ma… - Lung Cancer, 2020 - Elsevier
Background Currently, the main treatment for non-small cell lung cancer (NSCLC) is surgery
and chemotherapy. Although major progress has been made in targeted treatment and …
and chemotherapy. Although major progress has been made in targeted treatment and …
[HTML][HTML] Gemcitabine-resistant biomarkers in bladder cancer are associated with tumor-immune microenvironment
Y Song, Y Du, C Qin, H Liang, W Yang, J Lin… - Frontiers in Cell and …, 2022 - frontiersin.org
To identify key biomarkers in gemcitabine (GEM)-resistant bladder cancer (BCa) and
investigate their associations with tumor-infiltrating immune cells in tumor immune …
investigate their associations with tumor-infiltrating immune cells in tumor immune …
[HTML][HTML] Hypothesis-generating proteome perturbation to identify NEU-4438 and acoziborole modes of action in the African Trypanosome
NEU-4438 is a lead for the development of drugs against Trypanosoma brucei, which
causes human African trypanosomiasis. Optimized with phenotypic screening, targets of …
causes human African trypanosomiasis. Optimized with phenotypic screening, targets of …
[图书][B] Pituitary mechanisms regulating gonadotropin production and fertility in vivo
G Schang - 2019 - search.proquest.com
Despite major advances in assisted reproductive technologies, infertility remains a major
societal burden, with 1 in 6 couples unable to conceive a child naturally. Mammalian …
societal burden, with 1 in 6 couples unable to conceive a child naturally. Mammalian …