Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

The hippocampal formation is one of the most extensively studied regions of the brain, with
well-described anatomy and basic physiology; moreover, aspects of human memory …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Neurodegenerative diseases are conventionally demarcated as disorders with selective loss
of neurons. Conventional as well as newer molecules have been tested but they offer just …

Objective: There are significant unmet needs in the treatment of schizophrenia, especially for
the treatment of cognitive impairment, negative syndrome, and cognitive function. Preclinical …

Muscarinic acetylcholine receptors (mAChRs) are widely expressed in the CNS where they
control a variety of neuronal functions. Due to their roles in a number of CNS processes …

Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …

The discovery of allosteric modulators of G protein-coupled receptors (GPCRs) provides a
promising new strategy with potential for developing novel treatments for a variety of central …

Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …

Highlights•ACh boosts attention by enhancing sensory stimuli and decreasing cortico-
cortical communication.•Increased ACh signaling can lead to symptoms of depression in …