High folate, perturbed one-carbon metabolism and gestational diabetes mellitus

JM Williamson, AL Arthurs, MD Smith, CT Roberts… - Nutrients, 2022 - mdpi.com
Folate is a dietary micronutrient essential to one-carbon metabolism. The World Health
Organisation recommends folic acid (FA) supplementation pre-conception and in early …

Uncovering the hidden dangers and molecular mechanisms of excess folate: A narrative review

AM Fardous, AR Heydari - Nutrients, 2023 - mdpi.com
This review delves into the intricate relationship between excess folate (vitamin B9) intake,
especially its synthetic form, namely, folic acid, and its implications on health and disease …

Supplementation with (6S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolised folic acid …

KM Cochrane, R Elango, AM Devlin, C Mayer… - British Journal of …, 2024 - cambridge.org
Folic acid supplementation is recommended during pregnancy to support healthy fetal
development;(6S)-5-methyltetrahydrofolic acid ((6S)-5-MTHF) is available in some …

Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring

Y Qu, X Liu, S Lin, MS Bloom, X Wang, X Li… - JAMA Network …, 2024 - jamanetwork.com
Importance The association of folate supplementation with congenital heart disease (CHD)
prevention is controversial. Objective To examine the association of maternal serum folate …

Dietary supplements, guideline alignment and biochemical nutrient status in pregnancy: Findings from the Queensland Family Cohort pilot study

LA Gallo, SE Steane, SL Young… - Maternal & child …, 2024 - Wiley Online Library
In high‐income nations, multiple micronutrient (MMN) supplementation during pregnancy is
a common practice. We aimed to describe maternal characteristics associated with …

Vitamins and Human Health: Systematic Reviews and Original Research

T Barker - Nutrients, 2023 - mdpi.com
Vitamins are a group of organic compounds essential to physiological functions in the body.
This Special Issue features systematic review and original research articles of vitamins in …

Higher concentrations of folic acid cause oxidative stress, acute cytotoxicity, and long-term Fibrogenic changes in kidney epithelial cells

R Kandel, KP Singh - Chemical research in toxicology, 2022 - ACS Publications
Kidney fibrosis is a common step during chronic kidney disease (CKD), and its incidence
has been increasing worldwide. Aberrant recovery after repeated acute kidney injury leads …

[HTML][HTML] Folic Acid and Selected Risk Factors for Fetal Heart Defects—Preliminary Study Results

A Kolmaga, E Trafalska, E Gaszyńska, J Murlewska… - Nutrients, 2024 - pmc.ncbi.nlm.nih.gov
Background: The available data on the relationship between diet/folic acid and congenital
heart disease (CHD) are not consistent. This study aimed to investigate the relationship …

Parental folic acid deficiency delays neurobehavioral development in rat offspring by inhibiting the differentiation of neural stem cells into neurons

G Zhang, Q Ren, Y Lin, D Zhou, L Huang, W Li… - The Journal of …, 2023 - Elsevier
Maternal folate status during pregnancy is associated with the neurodevelopment of
offspring; however, study results on the association between paternal folate status and …

Serum Concentrations of Folate Forms Following Supplementation of Multimicronutrients with 400 µg or 800 µg Mix of (6S)‐5‐Methyltetrahydrofolate and Folic Acid (1 …

R Obeid, E Rube, C Schön… - Molecular Nutrition & Food …, 2024 - Wiley Online Library
Scope A mixture of (6S)‐5‐methyltetrahydrofolate‐calcium salt ((6S)‐5‐MTHF‐Ca) and folic
acid (FA) from multimicronutrient supplements may show a dose‐dependent effect on serum …