Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …

Depression is a highly heterogeneous syndrome that bears only modest correlations with its
biological substrates, motivating a renewed interest in rethinking our approach to …

Although emerging evidence suggests that altered functional connectivity (FC) of large-scale
neural networks is associated with disturbances in individuals at high-risk for psychosis, the …

The thalamus has complex connections with the cortex and is involved in various cognitive
processes. However, little is known about the age-related changes of thalamo-cortical …

Objective Somatic symptoms are common comorbidities of major depressive disorder
(MDD), and negatively impact the course and severity of the disease. In order to enrich the …

Heterogeneity in symptom presentation, outcomes, and treatment response has long been
problematic for researchers aiming to identify biological markers of schizophrenia or …

Objective: Thalamus models of psychosis implicate association nuclei in the pathogenesis of
psychosis and mechanisms of cognitive impairment. Studies to date have provided …

Background Attention‐deficit/hyperactivity disorder (ADHD) is a highly complex and
heterogeneous disorder. Abnormal brain connectivity in ADHD might be influenced by …

Abstract Background The Toronto Adolescent and Youth (TAY) Cohort Study will
characterize the neurobiological trajectories of psychosis spectrum symptoms, functioning …

The thalamus is composed of multiple nuclei densely connected with the cortex in an
organized manner, forming parallel thalamocortical networks critical to sensory, motor, and …