Dendritic cells (DCs) and macrophages use various receptors to recognize foreign antigens
and to receive feedback control from adaptive immune cells. Although it was long believed …

Salmonella pathogenesis is dependent on its ability to invade and replicate within host cells.
Following invasion the bacteria remain within a modified phagosome known as the …

Brucella is an intracellular pathogen able to persist for long periods of time within the host
and establish a chronic disease. We show that soon after Brucella inoculation in intestinal …

Salmonella enterica serovars Typhi and Paratyphi are the causative agents of human
typhoid fever. Current typhoid vaccines are ineffective and are not widely used in endemic …

The paradigm of tolerogenic/immature versus inflammatory/mature dendritic cells has
dominated the recent literature regarding the role of these antigen-presenting cells in …

The activation threshold of cells in the immune system is often tuned by cell surface
molecules. The Fc receptors expressed on various hematopoietic cells constitute critical …

Excessive production of aldosterone leads to the development of hypertension and
cardiovascular disease by generating an inflammatory state that can be promoted by T cell …

Despite the recognized role of the T-bet transcription factor in the differentiation of Th1 cells,
T-bet-deficient mice can develop small numbers of IFN-γ-producing CD4 T cells. Although …

Dendritic cells (DC) are important APCs linking innate and adaptive immunity. During
analysis of the intracellular activities of Salmonella enterica in DC, we observed that viable …

Salmonella enterica is a frequent gastrointestinal pathogen with ability to cause diseases
ranging from local gastrointestinal inflammation and diarrhea to life‐threatening typhoid …