Currently, metformin is the first-line medication to treat type 2 diabetes mellitus (T2DM) in
most guidelines and is used daily by> 200 million patients. Surprisingly, the mechanisms …

Drug repurposing in cancer taps into the capabilities of existing drugs, initially designed for
other ailments, as potential cancer treatments. It offers several advantages over traditional …

Background Ulcerative colitis (UC) is a type of inflammatory bowel disease associated with
persistent inflammation. Animal studies proved the efficacy of metformin in UC. Aim To …

Metformin is the first‐line medication for type 2 diabetes. It is effective and safe, provided
some caution is taken in specific populations. In patients with chronic kidney disease …

To investigate the association between T2DM and IBD by bidirectional two-sample
Mendelian randomization (MR) to clarify the casual relationship. Independent genetic …

Aim Drug repurposing, utilizing electronic healthcare records (EHRs), offers a promising
alternative by repurposing existing drugs for new therapeutic indications, especially for …

Metformin is widely used drugs in the treatment of type 2 diabetes mellitus. However, the
mechanisms of action are complex and are still not fully understood yet. Metformin has a …

Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) show anti‐inflammatory
properties. Aim To evaluate their clinical impact on inflammatory bowel disease (IBD) …

Background Metformin exerts anti-inflammatory properties through a positive effect on
oxidative stress, gut barrier integrity, and the gut microbiota. Our aim was to evaluate the …

Osteoarthritis (OA) is a degenerative disease that affects the quality of life in elderly and
young populations. Current therapies using corticosteroids and non-steroidal anti …