[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

VJ Peschansky, C Wahlestedt - Epigenetics, 2014 - Taylor & Francis
Epigenetic regulation of gene expression is an increasingly well-understood concept that
explains much of the contribution of an organism's environment and experience to its …

Alteration of the micro RNA network during the progression of Alzheimer's disease

P Lau, K Bossers, R Janky, E Salta… - EMBO molecular …, 2013 - embopress.org
An overview of miRNAs altered in Alzheimer's disease (AD) was established by profiling the
hippocampus of a cohort of 41 late‐onset AD (LOAD) patients and 23 controls, showing …

Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings

L Smigielski, V Jagannath, W Rössler, S Walitza… - Molecular …, 2020 - nature.com
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …

The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing

G Barry, JA Briggs, DP Vanichkina, EM Poth… - Molecular …, 2014 - nature.com
Schizophrenia (SZ) is a complex disease characterized by impaired neuronal functioning.
Although defective alternative splicing has been linked to SZ, the molecular mechanisms …

[HTML][HTML] Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers

B Khavari, MJ Cairns - Cells, 2020 - mdpi.com
Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms
that causes very significant disability in young people. While schizophrenia has a strong …

miR-132/212 deficiency impairs tau metabolism and promotes pathological aggregation in vivo

PY Smith, J Hernandez-Rapp, F Jolivette… - Human molecular …, 2015 - academic.oup.com
Alzheimer's disease (AD) and related tauopathies comprise a large group of
neurodegenerative diseases associated with the pathological aggregation of tau protein …

[HTML][HTML] Molecular characterization of exosomes and their microRNA cargo in human follicular fluid: bioinformatic analysis reveals that exosomal microRNAs control …

M Santonocito, M Vento, MR Guglielmino, R Battaglia… - Fertility and sterility, 2014 - Elsevier
Objective To characterize well-represented microRNAs in human follicular fluid (FF) and to
ascertain whether they are cargo of FF exosomes and whether they are involved in the …

Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

[HTML][HTML] Personalized medicine in psychiatry: problems and promises

U Ozomaro, C Wahlestedt, CB Nemeroff - BMC medicine, 2013 - Springer
The central theme of personalized medicine is the premise that an individual's unique
physiologic characteristics play a significant role in both disease vulnerability and in …