Mast cells are important effector cells of the immune system and recent studies show that
they have immunomodulatory roles in diverse processes in both health and disease. Mast …

Mast cells can promote inflammation and other tissue changes in IgE-associated allergic
disorders, as well as in certain innate and adaptive immune responses that are thought to be …

The physiological functions of mast cells remain largely an enigma. In the context of barrier
damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E …

Mast cells are widely distributed in tissues, particularly near surfaces exposed to the
environment. Mast cells can be activated to secrete diverse mediators and cytokines by IgE …

Mast cells (MCs) are currently receiving increased attention among the scientific community,
largely because of the recent identification of crucial functions for MCs in a variety of …

Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice
suggest key roles for mast cells in certain antibody-and T cell-mediated autoimmune …

Mast cells are rich in proteases, which are the major proteins of intracellular granules and
are released with histamine and heparin by activated cells. Most of these proteases are …

Mast cells (MCs) are traditionally thought of as a nuisance for its host, for example, by
causing many of the symptoms associated with allergic reactions. In addition, recent …

Mast cells (MCs) promote a wide range of localized and systemic inflammatory responses.
Their involvement in immediate as well as chronic inflammatory reactions at both local and …

Observations of increased numbers of mast cells at sites of chronic inflammation have been
reported for over a hundred years. Light and electron microscopic evidence of mast cell …