Antibody-drug conjugates (ADCs) provide effective cancer treatment through the selective
delivery of cytotoxic payloads to the cancer cells. They offer unparalleled precision and …

Simple Summary Since the first antibody–drug conjugate (ADC) was approved in 2000, the
landscape of these targeted drugs has evolved over the years, profoundly changing the …

Platinum compounds such as cisplatin, carboplatin and oxaliplatin are widely used in
chemotherapy. Cisplatin induces cytotoxic DNA damage that blocks DNA replication and …

Monoclonal antibody (mAb)-based and/or cell-based immunotherapies provide innovative
approaches to cancer treatments. However, safety concerns over targeting normal cells …

CD44 is a type I transmembrane glycoprotein associated with poor prognosis in various
solid tumors. Since CD44 plays a critical role in tumor development by regulating cell …

The evolving development landscape of biotherapeutics and their growing complexity from
simple antibodies into bi-and multi-specific molecules necessitates sophisticated discovery …

Immunology was one of the first biological fields to embrace chemical approaches. The
development of new chemical approaches and techniques has provided immunologists with …

Antineoplastic therapy is one of the main research themes of this century. Modern
approaches have been implemented to target and heighten the effect of cytostatic drugs on …

Antibodies and their derivatives (scFv, Fabs, etc.) represent a unique class of biomolecules
that combine selectivity with the ability to target drug delivery. Currently, one of the most …

Tag-free protein modification has received considerable attention in the field of chemical
biology owing to the versatility and simplicity of the reaction sequence. In 2021, a novel tag …