[HTML][HTML] A review of broadly protective monoclonal antibodies to treat Ebola virus disease
P Rijal, FR Donnellan - Current Opinion in Virology, 2023 - Elsevier
Highlights•mAbs mixture targeting independent epitopes are better therapeutics.•Optimizing
antibody efficacy: in vitro maturation, afucosylation, Fc modifications.•Monitoring of natural …
antibody efficacy: in vitro maturation, afucosylation, Fc modifications.•Monitoring of natural …
Vaccination induces broadly neutralizing antibody precursors to HIV gp41
A key barrier to the development of vaccines that induce broadly neutralizing antibodies
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
De Novo Design of Polyhedral Protein Assemblies: Before and After the AI Revolution
BB Mallik, J Stanislaw, TM Alawathurage… - …, 2023 - Wiley Online Library
Self‐assembling polyhedral protein biomaterials have gained attention as engineering
targets owing to their naturally evolved sophisticated functions, ranging from protecting …
targets owing to their naturally evolved sophisticated functions, ranging from protecting …
Neutralizing antibodies to block viral entry and for identification of entry inhibitors
EH Tam, Y Peng, MXY Cheah, C Yan, T Xiao - Antiviral Research, 2024 - Elsevier
Neutralizing antibodies (NAbs) are naturally produced by our immune system to combat viral
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …
infections. Clinically, neutralizing antibodies with potent efficacy and high specificity have …
Computational modeling and prediction of deletion mutants
In-frame deletion mutations can result in disease. The impact of these mutations on protein
structure and subsequent functional changes remain understudied, partially due to the lack …
structure and subsequent functional changes remain understudied, partially due to the lack …
[HTML][HTML] Strategies of rational and structure-driven vaccine design for Arenaviruses
AS Peter, DS Hoffmann, J Klier, CM Lange… - Infection, Genetics and …, 2024 - Elsevier
The COVID-19 outbreak has highlighted the importance of pandemic preparedness for the
prevention of future health crises. One virus family with high pandemic potential are …
prevention of future health crises. One virus family with high pandemic potential are …
[HTML][HTML] Anti-Ebola virus mAb 3A6 with unprecedented potency protects highly viremic animals from fatal outcome and physically lifts its glycoprotein target from the …
Monoclonal antibodies (mAbs) against Ebola virus (EBOV) glycoprotein (GP 1, 2) are the
standard of care for Ebola virus disease (EVD). Anti-GP 1, 2 mAbs targeting the stalk and …
standard of care for Ebola virus disease (EVD). Anti-GP 1, 2 mAbs targeting the stalk and …
Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5
Despite recent success in licencing of two malaria vaccines, there continues to be an urgent
need for improved vaccine immunogens as the world aims for malaria eradication. The …
need for improved vaccine immunogens as the world aims for malaria eradication. The …
The outbreak of the Ebola virus: Concerns for the animal-to-human spillover
Z Yang, H Yuan, XX Zhang, J Zhai… - Journal of medical …, 2023 - pubmed.ncbi.nlm.nih.gov
The outbreak of the Ebola virus: Concerns for the animal-to-human spillover The outbreak of
the Ebola virus: Concerns for the animal-to-human spillover J Med Virol. 2023 Jan;95(1):e28398 …
the Ebola virus: Concerns for the animal-to-human spillover J Med Virol. 2023 Jan;95(1):e28398 …