Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome

E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …

[HTML][HTML] Estrogen as a key regulator of energy homeostasis and metabolic health

F Mahboobifard, MH Pourgholami, M Jorjani… - Biomedicine & …, 2022 - Elsevier
Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …

Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry

ME Nilsson, L Vandenput, Å Tivesten, AK Norlén… - …, 2015 - academic.oup.com
Accurate measurement of sex steroid concentrations in rodent serum is essential to evaluate
mouse and rat models for sex steroid-related disorders. The aim of the present study was to …

New perspectives on the pathogenesis of PCOS: neuroendocrine origins

KA Walters, RB Gilchrist, WL Ledger, HJ Teede… - Trends in Endocrinology …, 2018 - cell.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
aged women. It is characterized by reproductive, endocrine, metabolic, and psychological …

Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

ASL Caldwell, MC Edwards, R Desai… - Proceedings of the …, 2017 - National Acad Sciences
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by
reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain …

The mechanism of androgen actions in PCOS etiology

V Rodriguez Paris, MJ Bertoldo - Medical sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
age women. By comprising reproductive, endocrine, metabolic and psychological features …

Endocrine disrupting chemicals in polycystic ovary syndrome: the relevant role of the theca and granulosa cells in the pathogenesis of the ovarian dysfunction

M Jozkowiak, H Piotrowska-Kempisty, D Kobylarek… - Cells, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder
among women of reproductive age. The pathogenesis of PCOS remains elusive; however …

A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice

AS Kauffman, VG Thackray, GE Ryan… - Biology of …, 2015 - academic.oup.com
Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack
of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat …

[HTML][HTML] Non-alcoholic fatty liver disease in women–current knowledge and emerging concepts

PC Eng, R Forlano, T Tan, P Manousou, WS Dhillo… - JHEP Reports, 2023 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide,
affecting up to 30% of adults. Progression to non-alcoholic steatohepatitis (NASH) is a key …

The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS)

EA Coutinho, AS Kauffman - Medical Sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting
at least 10% of women of reproductive age. PCOS is typically characterized by the presence …