Animal models to understand the etiology and pathophysiology of polycystic ovary syndrome
E Stener-Victorin, V Padmanabhan… - Endocrine …, 2020 - academic.oup.com
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …
(PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its …
[HTML][HTML] Estrogen as a key regulator of energy homeostasis and metabolic health
Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
Measurement of a comprehensive sex steroid profile in rodent serum by high-sensitive gas chromatography-tandem mass spectrometry
ME Nilsson, L Vandenput, Å Tivesten, AK Norlén… - …, 2015 - academic.oup.com
Accurate measurement of sex steroid concentrations in rodent serum is essential to evaluate
mouse and rat models for sex steroid-related disorders. The aim of the present study was to …
mouse and rat models for sex steroid-related disorders. The aim of the present study was to …
New perspectives on the pathogenesis of PCOS: neuroendocrine origins
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
aged women. It is characterized by reproductive, endocrine, metabolic, and psychological …
aged women. It is characterized by reproductive, endocrine, metabolic, and psychological …
Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome
ASL Caldwell, MC Edwards, R Desai… - Proceedings of the …, 2017 - National Acad Sciences
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by
reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain …
reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain …
The mechanism of androgen actions in PCOS etiology
V Rodriguez Paris, MJ Bertoldo - Medical sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-
age women. By comprising reproductive, endocrine, metabolic and psychological features …
age women. By comprising reproductive, endocrine, metabolic and psychological features …
Endocrine disrupting chemicals in polycystic ovary syndrome: the relevant role of the theca and granulosa cells in the pathogenesis of the ovarian dysfunction
M Jozkowiak, H Piotrowska-Kempisty, D Kobylarek… - Cells, 2022 - mdpi.com
Polycystic ovary syndrome (PCOS) is the most common heterogeneous endocrine disorder
among women of reproductive age. The pathogenesis of PCOS remains elusive; however …
among women of reproductive age. The pathogenesis of PCOS remains elusive; however …
A novel letrozole model recapitulates both the reproductive and metabolic phenotypes of polycystic ovary syndrome in female mice
AS Kauffman, VG Thackray, GE Ryan… - Biology of …, 2015 - academic.oup.com
Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack
of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat …
of PCOS animal models fully recapitulating this complex disorder. Recently, a PCOS rat …
[HTML][HTML] Non-alcoholic fatty liver disease in women–current knowledge and emerging concepts
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide,
affecting up to 30% of adults. Progression to non-alcoholic steatohepatitis (NASH) is a key …
affecting up to 30% of adults. Progression to non-alcoholic steatohepatitis (NASH) is a key …
The role of the brain in the pathogenesis and physiology of polycystic ovary syndrome (PCOS)
EA Coutinho, AS Kauffman - Medical Sciences, 2019 - mdpi.com
Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder, affecting
at least 10% of women of reproductive age. PCOS is typically characterized by the presence …
at least 10% of women of reproductive age. PCOS is typically characterized by the presence …