The most common genetic cause of neonatal diabetes and hyperinsulinism is pathogenic
variants in ABCC8 and KCNJ11. These genes encode the subunits of the β‐cell ATP …

Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

Congenital hyperinsulinism is a rare disease, but is the most frequent cause of persistent
and severe hypoglycaemia in early childhood. Hypoglycaemia caused by excessive and …

The ATP-sensitive potassium channel (KATP channel) couples blood levels of glucose to
insulin secretion from pancreatic β-cells. KATP channel closure triggers a cascade of events …

Congenital hyperinsulinism is characterised by the inappropriate release of insulin during
hypoglycaemia. This potentially life-threatening disorder can occur in isolation, or present as …

Objective Aim was to identify hypotheses why adverse neurodevelopment still occurs in
children with transient or persistent hyperinsulinism despite improvements in long-term …

Introduction: Diazoxide is the first line and only Federal Drug Agency approved
pharmacological agent for the treatment of hyperinsulinism. Its use has increased over the …

Context The management of congenital hyperinsulinism (CHI) has improved. Objective To
examine the treatment and long-term outcome of Finnish patients with persistent and …

Background Infantile spasms represent the catastrophic, age-specific seizure type
associated with acute and long-term neurological morbidity. However, due to rarity and …

Genetic characteristics of patients with congenital hyperins... : Current Opinion in Pediatrics
Genetic characteristics of patients with congenital hyperinsulinism : Current Opinion in …