Targeted radiotherapy or endoradiotherapy is an appealing approach to cancer treatment
because of the potential for delivering curative doses of radiation to tumor while sparing …

Abstract 211At is a promising radionuclide for α-particle therapy of cancers. Its physical
characteristics make this radionuclide particularly interesting to consider when bound to …

An investigation has been conducted to assess the in vivo stability of a series of astatinated
benzamides and astatinated nido-carborane compounds in mice. It was hypothesized that …

Radionuclides which decay by the emission of α-particles are attractive for certain
radioimmunotherapeutic applications. These include the treatment of lymphomas …

Recent advances in the field of nanotechnology application in nuclear medicine offer the
promise of better therapeutic options. In recent years, increasing efforts have been made on …

PURPOSE To review antibody structure, function, and production; suitable radioisotopes for
radioimmunotherapy; challenges facing the field; recent clinical results; toxicity; and future …

Targeted α-particle therapy (TAT) is an attractive alternative to conventional therapy for
cancer treatment. Among the available radionuclides considered for TAT, astatine-211 …

Alpha particle-emitting radionuclides have gained considerable attention for radionuclide
therapy. Astatine-211 (211At) is a promising alpha particle-emitting radionuclide. 211At is a …

Alpha particle emitting isotopes are of considerable interest for radionuclide therapy
because of their high cytotoxicity and short path length. Due to the relatively high availability …

Cancer-targeting biomolecules labeled with 211At must be stable to in vivo deastatination,
as control of the 211At distribution is critical due to the highly toxic nature of α-particle …