Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and
many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer …

The sulfur biochemistry of the thiol group endows cysteines with a number of highly
specialized and unique features that enable them to serve a variety of different functions in …

Ever since the “great oxidation event,” Earth's cellular life forms had to cope with the danger
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …

An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …

Mammalian tissues engage in specialized physiology that is regulated through reversible
modification of protein cysteine residues by reactive oxygen species (ROS). ROS regulate a …

Cysteine is one of the least abundant amino acids, yet it is frequently found as a highly
conserved residue within functional (regulatory, catalytic, or binding) sites in proteins. It is …

The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Oxic environments are hazardous. Molecular oxygen adventitiously abstracts electrons from
many redox enzymes, continuously forming intracellular superoxide and hydrogen peroxide …

Significance: The detrimental effects of ionizing radiation (IR) involve a highly orchestrated
series of events that are amplified by endogenous signaling and culminating in oxidative …

Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …