Caspase-3 is a widely expressed member of a conserved family of proteins, generally
recognized for their activated proteolytic roles in the execution of apoptosis in cells …

Organismal development and function requires multiple and accurate signal transduction
pathways to ensure that proper balance between cell proliferation, differentiation …

The phenotypic and biochemical similarities between caspase-mediated apoptosis and
cellular differentiation are striking. They include such diverse phenomenon as mitochondrial …

Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to
shrink tumors. Crucial for apoptotic function are executioner caspases, most notably …

Facioscapulohumeral muscular dystrophy (FSHD) is characterised by progressive skeletal
muscle weakness and wasting. FSHD is linked to epigenetic derepression of the …

The conserved p38 MAPK family is activated by phosphorylation during stress responses
and inactivated by phosphatases. C. elegans PMK-1 p38 MAPK initiates innate immune …

Cell-surface markers for prospective isolation of stem cells from human skeletal muscle have
been difficult to identify. Such markers would be powerful tools for studying satellite cell …

Muscle atrophy derived from excessive proteolysis is a hallmark of numerous disease
conditions. Accordingly, the negative consequences of skeletal muscle protein breakdown …

Apoptosis, the most extensively studied form of programmed cell death, is essential for
organismal homeostasis. Apoptotic cell death has widely been reported as a tumor …

Abstract Background Procaspase-3 (PC-3) is overexpressed in multiple tumour types and
procaspase-activating compound 1 (PAC-1) directly activates PC-3 and induces apoptosis …