Advances in biomaterials and technologies for vascular embolization

J Hu, H Albadawi, BW Chong, AR Deipolyi… - Advanced …, 2019 - Wiley Online Library
Minimally invasive transcatheter embolization is a common nonsurgical procedure in
interventional radiology used for the deliberate occlusion of blood vessels for the treatment …

Clinically established biodegradable long acting injectables: an industry perspective

CI Nkanga, A Fisch, M Rad-Malekshahi… - Advanced drug delivery …, 2020 - Elsevier
Long acting injectable formulations have been developed to sustain the action of drugs in
the body over desired periods of time. These delivery platforms have been utilized for both …

Basics of dermal filler rheology

S Pierre, S Liew, A Bernardin - Dermatologic surgery, 2015 - journals.lww.com
BACKGROUND Hyaluronic acid injectable fillers are the most widely used dermal fillers to
treat facial volume deficits, providing long-term facial aesthetic enhancement outcomes for …

High-concentration protein formulations: how high is high?

P Garidel, AB Kuhn, LV Schäfer… - European Journal of …, 2017 - Elsevier
High-concentration protein formulation (HCPF) is a term that is used to describe protein
formulations, mostly monoclonal antibody (mAb) drugs, at high protein concentration. The …

Mucoadhesive chitosan hydrogels as rectal drug delivery vessels to treat ulcerative colitis

J Xu, M Tam, S Samaei, S Lerouge, J Barralet… - Acta biomaterialia, 2017 - Elsevier
Mucoadhesive drug delivery systems stick to mucosal tissues and prolong the local retention
time of drugs. Since the colon is covered by a mucosal layer, mucoadhesive rectal …

Injectable gelatin microgel-based composite ink for 3D bioprinting in air

K Song, AM Compaan, W Chai… - ACS applied materials & …, 2020 - ACS Publications
Injectable hydrogels have attracted much attention in tissue engineering and regenerative
medicine for their capability to replace implantation surgeries with a minimally invasive …

Silk-elastinlike protein-based hydrogels for drug delivery and embolization

E Griswold, J Cappello, H Ghandehari - Advanced Drug Delivery Reviews, 2022 - Elsevier
Abstract Silk-Elastinlike Protein-Based Polymers (SELPs) can form thermoresponsive
hydrogels that allow for the generation of in-situ drug delivery matrices. They are produced …

Current state and opportunities with long-acting injectables: industry perspectives from the innovation and quality consortium “long-acting injectables” working group

A Bauer, P Berben, SS Chakravarthi… - Pharmaceutical …, 2023 - Springer
Long-acting injectable (LAI) formulations can provide several advantages over the more
traditional oral formulation as drug product opportunities. LAI formulations can achieve …

Integrated data-driven modeling and experimental optimization of granular hydrogel matrices

CA Verheyen, SGM Uzel, A Kurum, ET Roche… - Matter, 2023 - cell.com
Granular hydrogel matrices have emerged as promising candidates for cell encapsulation,
bioprinting, and tissue engineering. However, it remains challenging to design and optimize …

Modeling, design, and machine learning-based framework for optimal injectability of microparticle-based drug formulations

M Sarmadi, AM Behrens, KJ McHugh… - Science …, 2020 - science.org
Inefficient injection of microparticles through conventional hypodermic needles can impose
serious challenges on clinical translation of biopharmaceutical drugs and microparticle …