Hormonal treatments for major depressive disorder: state of the art

JB Dwyer, A Aftab, R Radhakrishnan… - American Journal of …, 2020 - Am Psychiatric Assoc
Major depressive disorder is a common psychiatric disorder associated with marked
suffering, morbidity, mortality, and cost. The World Health Organization projects that by 2030 …

Altering the course of schizophrenia: progress and perspectives

MJ Millan, A Andrieux, G Bartzokis… - Nature reviews Drug …, 2016 - nature.com
Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …

More than a marker: potential pathogenic functions of MAP2

RA DeGiosio, MJ Grubisha, ML MacDonald… - Frontiers in molecular …, 2022 - frontiersin.org
Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders–A comprehensive systematic review and meta-analysis

R Jeppesen, RHB Christensen, EMJ Pedersen… - Brain, behavior, and …, 2020 - Elsevier
Objective Antipsychotic effects of immunomodulating drugs have been suggested; however,
a thorough, comprehensive meta-analysis on the effect and safety of anti-inflammatory add …

Adjunctive use of anti-inflammatory drugs for schizophrenia: a meta-analytic investigation of randomized controlled trials

M Cho, TY Lee, YB Kwak, YB Yoon… - Australian & New …, 2019 - journals.sagepub.com
Objective: Recent evidence suggests that adjuvant anti-inflammatory agents could improve
the symptoms of patients with schizophrenia. However, the effects of the adjuvant anti …

Cognitive deficit in schizophrenia: from etiology to novel treatments

AL Martínez, J Brea, S Rico, MT De los Frailes… - International journal of …, 2021 - mdpi.com
Schizophrenia is a major mental illness characterized by positive and negative symptoms,
and by cognitive deficit. Although cognitive impairment is disabling for patients, it has been …

Early interventions in risk groups for schizophrenia: what are we waiting for?

IE Sommer, CE Bearden, E Van Dellen, EJ Breetvelt… - npj …, 2016 - nature.com
Intervention strategies in adolescents at ultra high-risk (UHR) for psychosis are promising for
reducing conversion to overt illness, but have only limited impact on functional outcome …

Neurosteroid actions in memory and neurologic/neuropsychiatric disorders

MH Ratner, V Kumaresan, DH Farb - Frontiers in endocrinology, 2019 - frontiersin.org
Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric
disorders; however, the basic underlying mechanisms of memory and altered states of …

Neurosteroids and potential therapeutics: focus on pregnenolone

M Vallée - The Journal of steroid biochemistry and molecular …, 2016 - Elsevier
Considerable evidence from preclinical and clinical studies shows that steroids and in
particular neurosteroids are important endogenous modulators of several brain-related …

Multimodal electrophysiological analyses reveal that reduced synaptic excitatory neurotransmission underlies seizures in a model of NMDAR antibody-mediated …

SK Wright, RE Rosch, MA Wilson, MA Upadhya… - Communications …, 2021 - nature.com
Seizures are a prominent feature in N-Methyl-D-Aspartate receptor antibody (NMDAR
antibody) encephalitis, a distinct neuro-immunological disorder in which specific human …