The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding
functions that participate in regulation of cell fate in a wide range of cellular systems and are …

Accumulation of unwanted/misfolded proteins in aggregates has been observed in airways
of patients with cystic fibrosis (CF), a life-threatening genetic disorder caused by mutations in …

The human transglutaminase (TG) family consists of a structural protein, protein 4.2, that
lacks catalytic activity, and eight zymogens/enzymes, designated factor XIII-A (FXIII-A) and …

Transglutaminase 2 (TG2 or tissue transglutaminase) is a highly complex multifunctional
protein that acts as transglutaminase, GTPase/ATPase, protein disulfide isomerase, and …

Although peroxisome proliferator-activated receptor γ (PPARγ) has anti-inflammatory actions
in macrophages, which macrophage populations express PPARγ in vivo and how it …

Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by
genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine …

Background An unresolved question in coeliac disease is to understand how some toxic
gliadin peptides, in particular p31–43, can initiate an innate response and lead to tissue …

Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth that
contributes significantly to morbidity and mortality in neonatal intensive care units. BPD …

The airway epithelium works as a physical barrier between the external environment and
internal structures, which represent the lung's first defense against inhaled microorganisms …