Tailoring of chitosan through the involvement of its amino, acetamido, and hydroxy groups
can give derivatives of enhanced solubility and remarkable anticancer activity. The general …

Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine
binding site is one of the most important pockets for potential tubulin polymerization …

Despite remarkable progress in the discovery and development of novel cancer
therapeutics, cancer remains the second leading cause of death in the world. For many …

Lycopene is an aliphatic hydrocarbon carotenoid extracted from plants like tomatoes,
papayas, and watermelons. Previous studies have shown that lycopene can exert …

Microtubules (composed of α-and β-tubulin heterodimers) play a pivotal role in mitosis and
cell division, and are regarded as an excellent target for chemotherapeutic agents to treat …

Nanomedicine greatly improves the efficiency in the delivery of antitumor drugs into the
tumor, but insufficient tumoral penetration impairs the therapeutic efficacy of most …

The search for new lead compounds of simple structure, displaying highest quality anti-
tumor potency with new mechanisms of action and least adverse effects is the major …

Introduction: Colchicine has been successfully used for the treatment of neutrophilic
disorders such as familial Mediterranean fever (FMF), Behçet disease (BD) and gout. There …

Microtubules are essential for the mitotic division of cells and have been an attractive target
for antitumour drugs due to the increased incidence of cancer and significant mitosis rate of …

Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-
target cell. However, diverse colchicine analogs have been derivatized as intentions for …