Neuregulin-ERBB signaling in the nervous system and neuropsychiatric diseases
Neuregulins (NRGs) comprise a large family of growth factors that stimulate ERBB receptor
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
tyrosine kinases. NRGs and their receptors, ERBBs, have been identified as susceptibility …
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease
DN Cooper, M Krawczak, C Polychronakos… - Human genetics, 2013 - Springer
Some individuals with a particular disease-causing mutation or genotype fail to express
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
most if not all features of the disease in question, a phenomenon that is known as 'reduced …
Genome-wide association studies in diverse populations
NA Rosenberg, L Huang, EM Jewett… - Nature Reviews …, 2010 - nature.com
Genome-wide association (GWA) studies have identified a large number of SNPs
associated with disease phenotypes. As most GWA studies have been performed in …
associated with disease phenotypes. As most GWA studies have been performed in …
Enteric nervous system development: migration, differentiation, and disease
JI Lake, RO Heuckeroth - American Journal of Physiology …, 2013 - journals.physiology.org
The enteric nervous system (ENS) provides the intrinsic innervation of the bowel and is the
most neurochemically diverse branch of the peripheral nervous system, consisting of two …
most neurochemically diverse branch of the peripheral nervous system, consisting of two …
Molecular genetic anatomy and risk profile of Hirschsprung's disease
Background Hirschsprung's disease, or congenital aganglionosis, is a developmental
disorder of the enteric nervous system and is the most common cause of intestinal …
disorder of the enteric nervous system and is the most common cause of intestinal …
The science of Hirschsprung disease: what we know and where we are headed
JL Mueller, AM Goldstein - Seminars in pediatric surgery, 2022 - Elsevier
The enteric nervous system (ENS) is a rich network of neurons and glial cells that comprise
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …
the gastrointestinal tract's intrinsic nervous system and are responsible for controlling …
Development and developmental disorders of the enteric nervous system
F Obermayr, R Hotta, H Enomoto… - Nature reviews …, 2013 - nature.com
The enteric nervous system (ENS) arises from neural crest-derived cells that migrate into
and along the gut, leading to the formation of a complex network of neurons and glial cells …
and along the gut, leading to the formation of a complex network of neurons and glial cells …
Discovery of common variants associated with low TSH levels and thyroid cancer risk
J Gudmundsson, P Sulem, DF Gudbjartsson… - Nature …, 2012 - nature.com
To search for sequence variants conferring risk of nonmedullary thyroid cancer, we focused
our analysis on 22 SNPs with a P< 5× 10− 8 in a genome-wide association study on levels …
our analysis on 22 SNPs with a P< 5× 10− 8 in a genome-wide association study on levels …
Building a brain in the gut: development of the enteric nervous system
AM Goldstein, RMW Hofstra, AJ Burns - Clinical genetics, 2013 - Wiley Online Library
The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, is an
essential component of the gut neuromusculature and controls many aspects of gut function …
essential component of the gut neuromusculature and controls many aspects of gut function …
[HTML][HTML] Development of the intrinsic and extrinsic innervation of the gut
T Uesaka, HM Young, V Pachnis, H Enomoto - Developmental biology, 2016 - Elsevier
The gastrointestinal (GI) tract is innervated by intrinsic enteric neurons and by extrinsic
efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of …
efferent and afferent nerves. The enteric (intrinsic) nervous system (ENS) in most regions of …