Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
antidepressant class today and exert their antidepressant-like effects by increasing synaptic …

Substantial evidence indicates that the lateral septum (LS) plays a critical role in regulating
processes related to mood and motivation. This review presents findings from the basic …

The effects of adrenal corticosteroids on subsequent adrenocorticotropin secretion are
complex. Acutely (within hours), glucocorticoids (GCs) directly inhibit further activity in the …

Its last edition hailed as" an essential volume for psychiatry residents as well as
clinicians"(Journal of Psychiatric Practice), The American Psychiatric Publishing Textbook of …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Corticotropin-releasing factor (CRF) and the related urocortin peptides mediate behavioral,
cognitive, autonomic, neuroendocrine and immunologic responses to aversive stimuli by …

Exposure to adverse experiences in early-life is implicated in the later vulnerability to
development of psychiatric disorders, including anxiety and affective disorders in humans …

Introduction 3. Stress potentiates a nociceptive response in humans 4. Animal models and
putative mechanisms of hyperalgesia 4.1. Acute stress-induced hyperalgesia 4.2. Chronic …

Neuropeptide Y (NPY) mediates its physiological effects through at least four receptors
known as Y1, Y2, Y4, and Y5. This peptide is one of the most abundant peptides in the …

The serotonin system is strongly implicated in the pathophysiology and therapeutic
alleviation of stress-related disorders such as anxiety and depression. Serotonergic …