The onset of multiple sclerosis (MS) in childhood poses diagnostic and therapeutic
challenges, particularly if the symptoms of the first demyelinating event resemble acute …

Abstract Knowledge of the epidemiology and natural history of multiple sclerosis (MS) is
essential for practitioners and patients to make informed decisions about their care. This …

Background The course and prognosis of childhood-onset multiple sclerosis have not been
well described. Methods We used data from 13 adult neurology departments affiliated with …

Background The full spectrum of clinical manifestations and outcome, and the potential
importance of regional or demographic features or viral triggers in paediatric multiple …

Objectives: To establish the prognostic role of clinical and demographic factors in a hospital-
based cohort of MS patients categorized by age at clinical onset and clinical course …

OBJECTIVES: To evaluate prognostic factors for second attack and for disability in children
presenting with an initial episode of central nervous system (CNS) demyelination. STUDY …

The prognostic factors for relapse of the initial MRI findings after a first episode of acute CNS
inflammatory demyelination are unclear in children. In this study we aimed to identify initial …

This Review summarizes the natural history studies on multiple sclerosis (MS) that have
evaluated prognostic factors. Reassessment of prognostic factors is warranted, as our ability …

OBJECTIVES: To describe the demographic and clinical characteristics of pediatric multiple
sclerosis (MS) in the United States. METHODS: This prospective observational study …

The authors studied CSF characteristics in 136 patients with multiple sclerosis (MS) with a
disease onset before age 16. In the initial diagnostic lumbar puncture, CSF-pleocytosis was …