Macrophages are heterogeneous and their phenotype and functions are regulated by the
surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) …

Cryptococcus neoformans (C. neoformans) is a pathogenic fungus with a global distribution.
Humans become infected by inhaling the fungus from the environment, and the fungus …

The opportunistic fungal pathogen Cryptococcus neoformans causes lethal infections in
immunocompromised patients. Macrophages are central to the host response to cryptococci; …

The blood-brain barrier (BBB) protects the central nervous system (CNS) by restricting the
passage of molecules and microorganisms. Despite this barrier, however, the fungal …

Sepsis is a host immune disorder induced by infection. It can lead to multiple organ
dysfunction syndrome (MODS), which has high morbidity and mortality. There has been …

Sporothrix schenckii sensu stricto and S. brasiliensis are usually associated to
sporotrichosis, a subcutaneous mycosis worldwide distributed. Comparative analyses …

The fungal pathogen Cryptococcus neoformans can cause life-threatening infections in
immune compromised individuals. This pathogen is typically acquired via inhalation, and …

Fungal pathogens are underappreciated causes of significant morbidity and mortality
worldwide. In previous studies, we determined that a heat-killed, Cryptococcus neoformans …

How lung macrophages, especially interstitial macrophages (IMs), respond to invading
pathogens remains elusive. Here, we show that mice exhibited a rapid and substantial …

Cryptococcal meningitis is the most common cause of meningitis among HIV/AIDS patients
in sub-Saharan Africa, and worldwide causes over 223,000 cases leading to more than …