Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Signal Transducers and Activators of Transcription (STATs) are a family of transcription
factors that regulate cell proliferation, differentiation, apoptosis, immune and inflammatory …

Aims MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the
post-transcriptional level by either degradation or translational repression of a target mRNA …

In the absence of effective endogenous repair mechanisms after cardiac injury, cell-based
therapies have rapidly emerged as a potential novel therapeutic approach in ischaemic …

Objectives Increasing evidences suggest that inducing mesenchymal stem cells to
differentiate into osteoblasts has been as an especially important component in the …

IL‐6‐type cytokines bind to plasma membrane receptor complexes containing the common
signal transducing receptor chain gp130 that is ubiquitously expressed in most tissues …

Directing differentiation of human embryonic stem cells (hESCs) into specific cell types using
an easy and reproducible protocol is a prerequisite for the clinical use of hESCs in …

Recent literature suggests that extracellular vesicles (EVs), secreted from most cells and
containing cell-specific cargo of proteins, lipids, and nucleic acids, are major driver of …

Accumulating evidence demonstrated that bone marrow‐derived mesenchymal stem cells
(BMSCs) may transdifferentiate into cardiomyocytes and replace apoptotic myocardium so …

Rationale: Glycogen synthase kinase (GSK)-3β upregulates cardiac genes in bone marrow–
derived mesenchymal stem cells (MSCs) in vitro. Ex vivo modification of signaling …