Lung cancer: New biological insights and recent therapeutic advances

SS Ramalingam, TK Owonikoko… - CA: a cancer journal for …, 2011 - Wiley Online Library
Approximately 1.6 million new cases of lung cancer are diagnosed each year throughout the
world. In many countries, the mortality related to lung cancer continues to rise. The outcomes …

[HTML][HTML] Systematic review and meta-analysis of randomised, phase II/III trials adding bevacizumab to platinum-based chemotherapy as first-line treatment in patients …

JC Soria, A Mauguen, M Reck, AB Sandler, N Saijo… - Annals of oncology, 2013 - Elsevier
Background Previous studies have demonstrated the efficacy and safety of bevacizumab in
the treatment of non-small-cell lung cancer (NSCLC). Methods Summary data from …

PARAMOUNT: final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed …

LG Paz-Ares, F de Marinis, M Dediu… - Journal of clinical …, 2013 - ascopubs.org
Purpose In the phase III PARAMOUNT trial, pemetrexed continuation maintenance therapy
reduced the risk of disease progression versus placebo (hazard ratio [HR], 0.62; 95% CI …

Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 …

T Ciuleanu, T Brodowicz, C Zielinski, JH Kim… - The Lancet, 2009 - thelancet.com
Background Several studies have shown the efficacy, tolerability, and ease of administration
of pemetrexed—an antifolate antineoplastic agent—in patients with advanced non-small-cell …

Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21

ME Hatley, DM Patrick, MR Garcia, JA Richardson… - Cancer cell, 2010 - cell.com
Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell
lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is …

A phase III study of belagenpumatucel-L, an allogeneic tumour cell vaccine, as maintenance therapy for non-small cell lung cancer

G Giaccone, LA Bazhenova, J Nemunaitis… - European journal of …, 2015 - Elsevier
Background Treatment options after first-line chemotherapy are limited in non-small cell lung
cancer (NSCLC). Belagenpumatucel-L is a therapeutic vaccine comprised of 4 transforming …

Non–small cell lung cancer

DS Ettinger, W Akerley, H Borghaei, AC Chang… - Journal of the National …, 2012 - jnccn.org
Most patients with non–small cell lung cancer (NSCLC) are diagnosed with advanced
cancer. These guidelines only include information about stage IV NSCLC. Patients with …

Platinum-based chemotherapy in advanced non-small-cell lung cancer: optimal number of treatment cycles

A Rossi, M Di Maio - Expert review of anticancer therapy, 2016 - Taylor & Francis
Platinum-based chemotherapy remains the standard-of-care for most patients affected by
advanced non-small cell lung cancer (NSCLC). The platinum compounds currently used in …

[HTML][HTML] 2nd ESMO Consensus Conference on Lung Cancer: non-small-cell lung cancer first-line/second and further lines of treatment in advanced disease

B Besse, A Adjei, P Baas, P Meldgaard, M Nicolson… - Annals of …, 2014 - Elsevier
To complement the existing treatment guidelines for all tumour types, ESMO organises
consensus conferences to focus on specific issues in each type of tumour. The 2nd ESMO …

Prognostic influence of metformin as first‐line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes

BX Tan, WX Yao, J Ge, XC Peng, XB Du, R Zhang… - Cancer, 2011 - Wiley Online Library
BACKGROUND: It has been reported that antidiabetic drugs affect the risk of cancer and the
prognosis of patients with diabetes, but few studies have demonstrated the influence of …