Zebrafish as an animal model for biomedical research

TY Choi, TI Choi, YR Lee, SK Choe… - Experimental & Molecular …, 2021 - nature.com
Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

[HTML][HTML] Understanding the habenula: A major node in circuits regulating emotion and motivation

JL Ables, K Park, I Ibañez–Tallon - Pharmacological research, 2023 - Elsevier
Over the last decade, the understanding of the habenula has rapidly advanced from being
an understudied brain area with the Latin name 'habena” meaning “little rein”, to being …

Advances in zebrafish as a comprehensive model of mental disorders

L Wang, F Liu, Y Fang, J Ma, J Wang, L Qu… - Depression and …, 2023 - Wiley Online Library
As an important part in international disease, mental disorders seriously damage human
health and social stability, which show the complex pathogenesis and increasing incidence …

The zebrafish subcortical social brain as a model for studying social behavior disorders

Y Geng, RT Peterson - Disease models & mechanisms, 2019 - journals.biologists.com
Social behaviors are essential for the survival and reproduction of social species. Many, if
not most, neuropsychiatric disorders in humans are either associated with underlying social …

The zebrafish for preclinical psilocybin research

OA Syed, B Tsang, R Gerlai - Neuroscience & Biobehavioral Reviews, 2023 - Elsevier
In this review, we discuss the possible utility of zebrafish in research on psilocybin, a
psychedelic drug whose recreational use as well as possible clinical application are gaining …

[HTML][HTML] Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism

AJ Khalaj, FH Sterky, A Sclip, J Schwenk… - Journal of Cell …, 2020 - rupress.org
Neurexins are presynaptic adhesion molecules that organize synapses by binding to
diverse trans-synaptic ligands, but how neurexins are regulated is incompletely understood …

Impairments of cerebellar structure and function in a zebrafish KO of neuropsychiatric risk gene znf536

TY Kim, A Roychaudhury, HT Kim, TI Choi… - Translational …, 2024 - nature.com
Genetic variants in ZNF536 contribute to the risk for neuropsychiatric disorders such as
schizophrenia, autism, and others. The role of this putative transcriptional repressor in brain …

Age-dependent effects of chronic stress on zebrafish behavior and regeneration

A Henríquez Martínez, LC Ávila, MA Pulido… - Frontiers in …, 2022 - frontiersin.org
Stress can have a significant impact on many aspects of an organism's physiology and
behavior. However, the relationship between stress and regeneration, and how this …

A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish

A Koh, S Tao, Y Jing Goh, V Chaganty… - Human molecular …, 2020 - academic.oup.com
Neurexins are presynaptic transmembrane proteins that control synapse activity and are risk
factors for autism spectrum disorder. Zebrafish, a popular model for behavioral studies, has …

[HTML][HTML] A review of systems biology research of anxiety disorders

MS Mufford, D van der Meer, OA Andreassen… - Brazilian Journal of …, 2020 - SciELO Brasil
The development of “omic” technologies and deep phenotyping may facilitate a systems
biology approach to understanding anxiety disorders. Systems biology approaches …