Introduction Chronic urticaria (CU), including chronic spontaneous urticaria (CSU) and
chronic inducible urticaria (CIndU), is a prevalent, enduring, mast-cell driven condition that …

Drug hypersensitivity reactions are a serious concern in clinical practice because they can
be severe and result in lifelong sequelae. An accurate diagnosis and identification of the …

This study explores the innovative use of machine learning (ML) to identify novel tryptase
inhibitors from a library of FDA-approved drugs, with subsequent confirmation via molecular …

Identification of the molecular culprits of allergic reactions leveraged molecular allergology
applications in clinical laboratory medicine. Molecular allergology shifted the focus from …

The exponential rise in the prevalence of allergic diseases since the mid-twentieth century
has led to a genuine public health emergency and has also fostered major progress in …

Abstract Traditional Chinese medicine injections (TCMIs) is a new dosage form of Chinese
medicine, which plays a unique role in rescuing patients with critical illnesses that are …

Background Paired sampling of acute (aST) and basal (bST) serum tryptase has been
recommended when investigating patients with a suspected perioperative hypersensitivity …

Serum tryptase and drug hypersensitivity: why, how and what?... : Current Opinion in Allergy
and Clinical Immunology Serum tryptase and drug hypersensitivity: why, how and what? A …

The implementation of existing guidelines which consensually recommend paired tryptase
measurement is a persistent unmet need hampering optimal diagnosis of drug-induced …

Introduction: Tryptase is an important biomarker widely used in the laboratory confirmation of
severe hypersensitivity reactions, especially anaphylaxis. It also plays a crucial role in the …