Advanced glycation end products (AGEs) are potentially harmful and heterogeneous
molecules derived from nonenzymatic glycation. The pathological implications of AGEs are …

The excessive intake of alcohol is a serious public health problem, especially given the
severe damage provoked by chronic or prenatal exposure to alcohol that affects many …

Objective: Alcohol use disorder (AUD) and chronic pain are widespread conditions with
extensive public health burden. This review seeks to describe neuroanatomical links and …

Long-term alcohol use leads to persistent cognitive deficits that may be associated with
maladaptive changes in the neurocircuitry that mediates executive functions. Impairments …

After decades of uncertainties and drawbacks, the study on the role and significance of
acetaldehyde in the effects of ethanol seemed to have found its main paths. Accordingly, the …

Excessive drinking can damage brain tissue and cause cognitive dysfunction. Studies have
found that the early stage of neurodegenerative disease is closely related to heavy drinking …

Salsolinol is formed non-enzymatically when ethanol-derived acetaldehyde binds to
dopamine, yielding 2 distinct products, ie, salsolinol and isosalsolinol. Early animal studies …

This review analyzes literature that describes the behavioral effects of 2 metabolites of
ethanol (EtOH): acetaldehyde and salsolinol (a condensation product of acetaldehyde and …

Acetaldehyde, the first alcohol metabolite, is responsible for many pharmacological effects
that are not clearly distinguishable from those exerted by its parent compound. It alters motor …

Fetal alcohol spectrum disorders (FASD) is an umbrella term that describes a diverse set of
ethanol-induced defects. The phenotypic variation is generated by numerous factors …