Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune
system and neuroplasticity mechanisms under both physiological conditions and …

Increased production of peripheral cytokines and other pro-inflammatory markers has been
linked to psychiatric disorders such as major depressive disorder and post-traumatic stress …

Objective: This article outlines the consensus guidelines for symptomatic treatment for
children with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS) and Pediatric …

Aside from its roles in as a classical neurotransmitter involved in regulation of behavior,
noradrenaline (NA) has other functions in the CNS. This includes restricting the …

Neuroinflammation has been known to play a critical role in the pathogenesis of Alzheimer's
disease (AD) through amyloidogenesis. In a previous study, we found that systemic …

A growing body of evidence demonstrates the important role of the noradrenergic system in
the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …

The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While
cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic …

Damage to noradrenergic neurons in the locus coeruleus (LC) is a hallmark of Alzheimer's
disease (AD) and may contribute to disease progression. In 5xFAD transgenic mice, which …

Vagus nerve stimulation (VNS) is currently Food and Drug Administration-approved for
treatment of both medically refractory partial-onset seizures and severe, recurrent refractory …