Claudins are a tetraspan membrane protein multigene family that plays a structural and
functional role in constructing tight junctions. Claudins perform crucial roles in maintaining …

Abstract microRNAs (miRNAs) are a family of small noncoding RNAs that play a pivotal role
in the regulation of main biological and physiological processes, including cell cycle …

Background Estrogen receptor β (ERβ) has been reported to play an anti-cancer role in
breast cancer, but the regulatory mechanism by which ERβ exerts this effect is not clear …

Abstract Apoptosis signal kinase 1 (ASK 1) is a member of the mitogen-activated protein
kinase (MAPK) family that induces cells apoptosis including colorectal cancer (CRC). CRC …

Abstract Background Claudin-18 (CLDN18) is a highly specific tight junction protein of the
gastric mucosa. An isoform of CLDN18, the Claudin 18.2, has recently emerged as an …

Tight junctions (TJs) are an important component of cell connectivity; they maintain cell
polarity, permeability and adhesion, and participate in the regulation of cell proliferation and …

Abstract Background Claudin-6 (CLDN6), a member of CLDN family and a key component
of tight junction, has been reported to function as a tumor suppressor in breast cancer …

Claudins (CLDNs) are the most important tight junction proteins, which are mainly
expressed in endothelial cells or epithelial cells in a tissue-specific manner. As a member of …

Pancreatic cancer has a high mortality rate due to the absence of early symptoms and
subsequent late diagnosis; additionally, pancreatic cancer has a high resistance to radio …

Claudins are four-transmembrane proteins, which were found in tight junctions. They
maintain cell barriers and regulate cell differentiation and proliferation. They are involved in …