Protein neddylation: beyond cullin–RING ligases
RI Enchev, BA Schulman, M Peter - Nature reviews Molecular cell …, 2015 - nature.com
NEDD8 (neural precursor cell expressed developmentally downregulated protein 8) is a
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …
ubiquitin-like protein that activates the largest ubiquitin E3 ligase family, the cullin–RING …
E2s: structurally economical and functionally replete
DM Wenzel, KE Stoll, RE Klevit - Biochemical Journal, 2011 - portlandpress.com
Ubiquitination is a post-translational modification pathway involved in myriad cellular
regulation and disease pathways. The Ub (ubiquitin) transfer cascade requires three …
regulation and disease pathways. The Ub (ubiquitin) transfer cascade requires three …
Targeting neddylation E2s: a novel therapeutic strategy in cancer
YC Zheng, YJ Guo, B Wang, C Wang… - Journal of Hematology & …, 2021 - Springer
Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F
(UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part …
(UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part …
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes
R Hjerpe, Y Thomas, J Chen, A Zemla… - Biochemical …, 2012 - portlandpress.com
Ubiquitin and UBL (ubiquitin-like) modifiers are small proteins that covalently modify other
proteins to alter their properties or behaviours. Ubiquitin modification (ubiquitylation) targets …
proteins to alter their properties or behaviours. Ubiquitin modification (ubiquitylation) targets …
Structural insights into the conformation and oligomerization of E2∼ ubiquitin conjugates
Post-translational modification of proteins by ubiquitin (Ub) regulates a host of cellular
processes, including protein quality control, DNA repair, endocytosis, and cellular signaling …
processes, including protein quality control, DNA repair, endocytosis, and cellular signaling …
The NEDD8 modification pathway in plants
J Mergner, C Schwechheimer - Frontiers in plant science, 2014 - frontiersin.org
NEDD8, in plants and yeasts also known as RELATED TO UBIQUITIN (RUB), is an
evolutionarily conserved 76 amino acid protein highly related to ubiquitin. Like ubiquitin …
evolutionarily conserved 76 amino acid protein highly related to ubiquitin. Like ubiquitin …
[HTML][HTML] Neddylation, a novel paradigm in liver cancer
TC Delgado, L Barbier-Torres… - Translational …, 2018 - ncbi.nlm.nih.gov
Liver cancer is the sixth most prevailing cancer worldwide. Hepatocellular carcinoma (HCC),
the most common form of primary liver cancer, has a rather heterogeneous pathogenesis …
the most common form of primary liver cancer, has a rather heterogeneous pathogenesis …
High-affinity free ubiquitin sensors for quantifying ubiquitin homeostasis and deubiquitination
Ubiquitin (Ub) conjugation is an essential post-translational modification that affects nearly
all proteins in eukaryotes. The functions and mechanisms of ubiquitination are areas of …
all proteins in eukaryotes. The functions and mechanisms of ubiquitination are areas of …
Recognition and cleavage of related to ubiquitin 1 (Rub1) and Rub1-ubiquitin chains by components of the ubiquitin-proteasome system
Of all ubiquitin-like proteins, Rub1 (Nedd8 in mammals) is the closest kin of ubiquitin. We
show via NMR that structurally, Rub1 and ubiquitin are fundamentally similar as well …
show via NMR that structurally, Rub1 and ubiquitin are fundamentally similar as well …
Inhibition of neddylation causes meiotic arrest in mouse oocyte
M Yang, Y Jin, S Fan, X Liang, J Jia, Z Tan, T Huang… - Cell Cycle, 2019 - Taylor & Francis
Mammalian oocyte meiosis is a special form of cell division that provides haploid gametes
for fertilization. Unlike in mitosis, post-translational modifications (PTMs) are more crucial …
for fertilization. Unlike in mitosis, post-translational modifications (PTMs) are more crucial …