Targeting ferroptosis: paving new roads for drug design and discovery

Y Gu, Y Li, J Wang, L Zhang, J Zhang… - European Journal of …, 2023 - Elsevier
Ferroptosis, first proposed in 2012, is an iron-dependent form of regulated cell death
characterized by excessive polyunsaturated fatty acid oxidation. In the past decade …

Ferroptosis in lung cancer: a novel pathway regulating cell death and a promising target for drug therapy

N Xing, Q Du, S Guo, G Xiang, Y Zhang, X Meng… - Cell Death …, 2023 - nature.com
Lung cancer is a common malignant tumor that occurs in the human body and poses a
serious threat to human health and quality of life. The existing treatment methods mainly …

[HTML][HTML] IGF2BP3 is an essential N6-methyladenosine biotarget for suppressing ferroptosis in lung adenocarcinoma cells

X Xu, J Cui, H Wang, L Ma, X Zhang, W Guo, X Xue… - Materials Today Bio, 2022 - Elsevier
A lack of promising targets leads to poor prognosis in patients with lung adenocarcinoma
(LUAD). Therefore, it is urgent to identify novel therapeutic targets. The importance of the N 6 …

LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth

Z Li, Y Hu, H Zheng, M Li, Y Liu, R Feng, X Li… - Nature cell …, 2024 - nature.com
The mechanisms underlying the dynamic remodelling of cellular membrane phospholipids
to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, a …

[HTML][HTML] Identification of EGFR as an essential regulator in chondrocytes ferroptosis of osteoarthritis using bioinformatics, in vivo, and in vitro study

H Sun, G Peng, K Chen, Z Xiong, Y Zhuang, M Liu… - Heliyon, 2023 - cell.com
Objective The mechanisms of chondrocytes ferroptosis in osteoarthritis (OA) have not yet
been fully elucidated. This study aimed to identify key ferroptosis related genes (FRGs) …

Ferroptosis induction via targeting metabolic alterations in head and neck cancer

J Lee, JL Roh - Critical Reviews in Oncology/Hematology, 2023 - Elsevier
Ferroptosis is a newly regulated cell death induced by the accumulation of iron-mediated
lipid peroxidation. The alteration of cancer metabolism may contribute to proliferation …

Epigenetic mechanism of RBM15 in affecting cisplatin resistance in laryngeal carcinoma cells by regulating ferroptosis

Y Liang, H Zhong, Y Zhao, XM Tang, C Pan, J Sun… - Biology Direct, 2024 - Springer
Laryngeal carcinoma (LC) is a common cancer of the respiratory tract. This study aims to
investigate the role of RNA-binding motif protein 15 (RBM15) in the cisplatin (DDP) …

Iron, Ferroptosis, and Head and Neck Cancer

Y Teng, L Gao, AA Mäkitie, E Florek… - International Journal of …, 2023 - mdpi.com
Ferroptosis is an iron-dependent regulatory form of cell death characterized by the
accumulation of intracellular reactive oxygen species and lipid peroxidation. It plays a critical …

Lipid metabolism and its implications in tumor cell plasticity and drug resistance: what we learned thus far?

R Vishwa, B BharathwajChetty, S Girisa… - Cancer and Metastasis …, 2024 - Springer
Metabolic reprogramming, a hallmark of cancer, allows cancer cells to adapt to their specific
energy needs. The Warburg effect benefits cancer cells in both hypoxic and normoxic …

[HTML][HTML] The Emerging Role of Ferroptosis in EBV-Associated Cancer: Implications for Cancer Therapy

S He, C Luo, F Shi, J Zhou, L Shang - Biology, 2024 - mdpi.com
Simple Summary This review will discuss the connection between ferroptosis and Epstein–
Barr Virus as well as its associated cancers. It delves into both known and potential ways in …