A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition
E Heilmann, F Costacurta, S Geley… - Communications …, 2022 - nature.com
Protease inhibitors are among the most powerful antiviral drugs. However, for SARS-CoV-2
only a small number of protease inhibitors have been identified thus far and there is still a …
only a small number of protease inhibitors have been identified thus far and there is still a …
合成生物学在基于微生物载体肿瘤疫苗设计中的应用
谭子斌， 梁康， 陈有海 - 合成生物学, 2024 - synbioj.cip.com.cn
合成生物学有望创造具备独特优势的抗肿瘤微生物疫苗, 合成生物学改造的微生物更能适应肿瘤
微环境并在其中富集与增殖, 削弱或者逆转免疫抑制细胞的功能, 并增强肿瘤抗原的呈递 …
微环境并在其中富集与增殖, 削弱或者逆转免疫抑制细胞的功能, 并增强肿瘤抗原的呈递 …
Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
L Krismer, H Schöppe, S Rauch, D Bante, B Sprenger… - npj Viruses, 2024 - nature.com
Abstract The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an epidemic,
zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has …
zoonotically emerging pathogen initially reported in Saudi Arabia in 2012. MERS-CoV has …
Vesicular stomatitis virus as a platform for protease activity measurements
S Rauch, F Costacurta, D von Laer… - Current …, 2024 - Wiley Online Library
Protease inhibitors are among the most powerful antiviral drugs. They have been used
successfully against viruses, such as the human immunodeficiency virus (HIV), hepatitis C …
successfully against viruses, such as the human immunodeficiency virus (HIV), hepatitis C …
chronODE: A framework to integrate time-series multi-omics data based on ordinary differential equations combined with machine learning
Most functional genomic studies are conducted in steady-state conditions, therefore
providing a description of molecular processes at a particular moment of cell differentiation …
providing a description of molecular processes at a particular moment of cell differentiation …
Development of an RNA virus-based episomal vector with artificial aptazyme for gene silencing
R Komorizono, S Yoshizumi, K Tomonaga - Applied Microbiology and …, 2024 - Springer
RNA virus-based episomal vector (REVec), engineered from Borna disease virus, is an
innovative gene delivery tool that enables sustained gene expression in transduced cells …
innovative gene delivery tool that enables sustained gene expression in transduced cells …
Attenuating RNA Viruses with Expanded Genetic Codes to Evoke Adjustable Immune Response in PylRS-tRNA CUA Pyl Transgenic Mice
Z Zheng, X Wu, Y Wang, X Yang, H Chen, Y Shen… - Vaccines, 2023 - mdpi.com
Ribonucleic acid (RNA) viruses pose heavy burdens on public-health systems. Synthetic
biology holds great potential for artificially controlling their replication, a strategy that could …
biology holds great potential for artificially controlling their replication, a strategy that could …
Applications of synthetic biology in developing microbial-vectored cancer vaccines
Z TAN, K LIANG, Y CHEN - Synthetic Biology Journal, 2024 - synbioj.cip.com.cn
The development of cancer vaccines is confronted with significant challenges. Synthetic
biology emerges as a potent tool for addressing these challenges, due to its ability to modify …
biology emerges as a potent tool for addressing these challenges, due to its ability to modify …
Rational selection of an ideal oncolytic virus to address current limitations in clinical translation
Oncolytic virus therapy (OVT) is a promising modality that leverages the propensity of natural
or engineered viruses to selectively replicate in and kill cancer cells. Over the past …
or engineered viruses to selectively replicate in and kill cancer cells. Over the past …
[图书][B] Viral Vectors in Cancer Immunotherapy
Viral Vectors in Cancer Immunotherapy, Volume 379 in the International Review of Cell and
Molecular Biology presents the latest on cancer immunotherapy and how it has transformed …
Molecular Biology presents the latest on cancer immunotherapy and how it has transformed …