All roads lead to PP 2A: exploiting the therapeutic potential of this phosphatase
J Sangodkar, CC Farrington, K McClinch… - The FEBS …, 2016 - Wiley Online Library
Protein phosphatase 2A (PP 2A) is a serine/threonine phosphatase involved in the
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
regulation of many cellular processes. A confirmed tumor suppressor protein, PP 2A is …
Size and shape of protein molecules at the nanometer level determined by sedimentation, gel filtration, and electron microscopy
HP Erickson - Biological procedures online, 2009 - Springer
An important part of characterizing any protein molecule is to determine its size and shape.
Sedimentation and gel filtration are hydrodynamic techniques that can be used for this …
Sedimentation and gel filtration are hydrodynamic techniques that can be used for this …
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase
INTRODUCTION RNA cleavage and phosphorylation-dephosphorylation of the RNA
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
polymerase II (Pol II) C-terminal domain (CTD) are two regulatory mechanisms of …
Structural basis for sequence-specific recognition of DNA by TAL effectors
TAL (transcription activator–like) effectors, secreted by phytopathogenic bacteria, recognize
host DNA sequences through a central domain of tandem repeats. Each repeat comprises …
host DNA sequences through a central domain of tandem repeats. Each repeat comprises …
Serine/threonine phosphatases: mechanism through structure
Y Shi - Cell, 2009 - cell.com
The reversible phosphorylation of proteins is accomplished by opposing activities of kinases
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …
and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the …
Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling
V Janssens, J Goris - Biochemical Journal, 2001 - portlandpress.com
Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases,
minimally containing a well conserved catalytic subunit, the activity of which is highly …
minimally containing a well conserved catalytic subunit, the activity of which is highly …
TOR, a central controller of cell growth
T Schmelzle, MN Hall - Cell, 2000 - cell.com
Cell growth (increase in cell mass) and cell proliferation (increase in cell number) are
distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or …
distinct yet coupled processes that go hand-in-hand to give rise to an organ, organism, or …
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
N Jette, SP Lees-Miller - Progress in biophysics and molecular biology, 2015 - Elsevier
The DNA-dependent protein kinase (DNA-PK) is a serine/threonine protein kinase
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …
composed of a large catalytic subunit (DNA-PKcs) and the Ku70/80 heterodimer. Over the …
Synthesis and function of 3-phosphorylated inositol lipids
B Vanhaesebroeck, SJ Leevers… - Annual review of …, 2001 - annualreviews.org
▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …
Regulation of translation initiation by FRAP/mTOR
Regulation of protein synthesis in eukaryotes plays a critical role in development,
differentiation, cell cycle progression, cell growth, and apoptosis (Mathews et al. 2000) …
differentiation, cell cycle progression, cell growth, and apoptosis (Mathews et al. 2000) …